上海交通大学学报（医学版）

›› 2011, Vol. 31 ›› Issue (11): 1518-.doi: 10.3969/j.issn.1674-8115.2011.11.003

• 专题报道（双相障碍） • 上一篇    下一篇

5-HTTLPR基因多态与双相障碍及其情感气质类型的关联研究

苑成梅1, 禹顺英2, 李则挚1, 黄 佳1, 洪 武1, 钱伊萍2, 方贻儒1   

  1. 上海交通大学 |医学院附属精神卫生中心 1.心境障碍科, 2.遗传室研究室, 上海 200030
  • 出版日期:2011-11-28 发布日期:2011-11-29
  • 通讯作者: 方贻儒, 电子信箱: yirufang@yahoo.com.cn。
  • 作者简介:苑成梅（1975—）, 女, 副主任医师, 博士；电子信箱: yuanchengmei@yeah.net。
  • 基金资助:

    国家自然科学基金项目（30270494）；国家高技术研究发展计划（“八六三”计划）（2006AA02Z430）；“十五”国家科技攻关项目（2004BA720A21-02）；上海市卫生局公共卫生优秀青年人才项目（08GWQ075）；上海市卫生局青年科研项目（2007Y14）；上海交通大学医学院“重点学科建设”基金（沪交医科[2008]-6）

Association of 5HTTLPR gene polymorphisms with bipolar disorder and affective temperaments

YUAN Cheng-mei1, YU Shun-ying2, LI Ze-zhi1, HUANG Jia1, HONG Wu1, QIAN Yi-ping2, FANG Yi-ru1   

  1. 1.Department of Mood Disorder, 2.Department of Genetics, Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai 200030, China
  • Online:2011-11-28 Published:2011-11-29
  • Supported by:

    National Natural Science Foundation of China, 30270494；National High Technology Research and Development Program of China, “863” Program, 2006AA02Z430；National Key Technology Research and Development Program of China in “Tenth-Five Year Plan”, 2004BA720A21-02；Shanghai Municipal Health Bureau Foundation, 08GWQ075, 2007Y14；Shanghai Jiaotong University School of Medicine Foundation, 2008-6

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摘要：

目的 探讨5-羟色胺转运体基因启动子区域(5-HTTLPR)基因多态性与双相障碍的关联，分析其与双相障碍患者情感气质类型的相关性。方法 采用病例—对照研究设计，共纳入305例双相障碍患者和272名正常对照。用情感气质评定量表（TEMPS-A）评估情感气质类型，运用χ2检验、T检验或非参数检验、方差分析等统计学方法评估5-HTTLPR基因多态与双相障碍及其情感气质类型的相关性。结果 在女性中，5-HTTLPR L/S多态与双相障碍相关（基因型χ2=6.769，P=0.034；等位基因χ2=6.028，P=0.014）；5-HTTLPR L/S多态S等位基因与双相障碍患者的焦虑气质相关（t=8.248，P=0.005）；5-HTTLPRrs25531 A/G多态 LA等位基因与双相障碍患者的情感旺盛气质相关（Z=－2.205，P=0.027）。结论 5-HTTLPR基因多态性与女性双相障碍的患病情况相关，且能在一定程度上影响患者的某些情感气质。

关键词: 双相障碍, 5-羟色胺转运体基因启动子区域, 基因多态, 情感气质, 情感气质评定量表

Abstract:

Objective To explore the association of serotonin transporter gene-linked polymorphic region (5-HTTLPR) gene polymorphisms with bipolar disorder and affective temperaments. Methods Case-control design was adopted, and 305 patients with bipolar disorder and 272 normal controls were enrolled. Temperament Evaluation of Memphis, Pisa, Paris and San Diego-autoquestionnaire version (TEMPS-A) was employed to assess the affective temperaments. Chi-square test, T test, nonparametric test and ANOVA were used to explore the association of 5-HTTLPR gene polymorphisms with bipolar disorder and affective temperaments. Results 5-HTTLPR L/S polymorphisms were associated with bipolar disorder in females (genotype, χ2=6.769, P=0.034；allele, χ2=6.028, P=0.014）, S allele of 5-HTTLPR L/S polymorphisms was associated with anxious temperament of patients with bipolar disorder （t=8.248，P=0.005）, and LA allele of 5-HTTLPR rs25531 A/G polymorphisms was associated with hyperthymic temperament of patients with bipolar disorder （Z=-2.205，P=0.027）. Conclusion 5-HTTLPR gene polymorphisms are associated with the prevalence of bipolar disorder in females, which can also regulate the affective temperaments of patients with bipolar disorder in some degree.

Key words: bipolar disorder, serotonin transporter gene-linked polymorphic region, gene polymorphism, affective temperament, Temperament Evaluation of Memphis, Pisa, Paris and San Diego-autoquestionnaire version