上海交通大学学报（医学版）

›› 2011, Vol. 31 ›› Issue (11): 1523-.doi: 10.3969/j.issn.1674-8115.2011.11.004

• 专题报道（双相障碍） • 上一篇    下一篇

早年创伤与抑郁症和双相障碍的关系分析

黄 佳, 苑成梅, 李则挚, 王 振, 陈 俊, 王 勇, 洪 武, 易正辉, 吴志国, 胡莺燕, 曹 岚, 王凌霄, 方贻儒   

  1. 上海交通大学 医学院附属精神卫生中心心境障碍科, 上海 200030
  • 出版日期:2011-11-28 发布日期:2011-11-29
  • 通讯作者: 方贻儒, 电子信箱: yirufang@yahoo.com.cn。
  • 作者简介:黄 佳（1983—）, 女, 住院医师, 硕士；电子信箱: kittyhj_2000@yahoo.cn。
  • 基金资助:

    国家自然科学基金（30971047）；国家高技术研究发展计划（“八六三”计划）（2006AA02Z430）；“十五”国家科技攻关计划（2004BA720A21-02）；上海市卫生局公共卫生优秀青年人才项目（08GWQ075）；上海市卫生局青年科研项目（2007Y14）；上海市科委“登山行动计划”（064119533，20062008）；上海交通大学医学院“重点学科建设”基金（沪交医科[2008]-6）

Correlation of early trauma experience with depression and bipolar disorder

HUANG Jia, YUAN Cheng-mei, LI Ze-zhi, WANG Zhen, CHEN Jun, WANG Yong, HONG Wu, YI Zheng-hui, WU Zhi-guo, HU Ying-yan, CAO Lan, WANG Ling-xiao, FANG Yi-ru   

  1. Department of Mood Disorder, Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai 200030, China
  • Online:2011-11-28 Published:2011-11-29
  • Supported by:

    National Natural Science Foundation of China, 30971047；National High Technology Research and Development Program of China, “863” Program, 2006AA02Z430；National Key Technology Research and Development Program of China in “Tenth-Five Year Plan”, 2004BA720A21-02；Shanghai Municipal Health Bureau Foundation, 08GWQ075, 2007Y14；Shanghai Science and Technology Committee Foundation, 064119533, 2006-2008；Shanghai Jiaotong University School of Medicine Foundation, 2008-6

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摘要：

目的 分析早年创伤经历与抑郁症和双相障碍的关系。方法 研究纳入317例抑郁症患者和124例双相障碍患者。采用自制问卷收集患者一般资料（包括性别、年龄、文化程度、首次发病年龄、精神疾病遗传史、总病程、发作总次数、工作情况和家庭状态）；以早年创伤自评简表（包括普通创伤、躯体创伤、情感虐待和性创伤4个维度）评估早年创伤情况，并对两种疾病患者的得分情况进行非参数检验比较；采用Logistic回归分析不同类型早年创伤与抑郁症和双相障碍发生相关因素的关系。结果 双相障碍患者的普通创伤发生率及量表总分显著高于抑郁症患者（P<0.05）。在抑郁症患者中，普通创伤与患者家庭状态相关（P<0.001），躯体创伤与患者性别、家庭状态及工作情况存在显著关联（P<0.05），情感虐待与患者家庭状态和疾病总发作次数相关（P<0.05）。在双相障碍患者中，普通创伤与患者家庭状态和精神疾病遗传史存在存在显著关联（P<0.05），情感虐待与患者家庭状态存在显著关联（P<0.01），性创伤与患者性别相关（P<0.01）。结论 早年创伤经历与抑郁症和双相障碍具有关联性，不同创伤类型在两种疾病的发生和发展中的作用有所不同。

关键词: 早年创伤, 抑郁症, 双相障碍

Abstract:

Objective To explore the correlation of early trauma experience with depression and bipolar disorder. Methods Three hundred and seventeen patients with depression and 124 patients with bipolar disorder were enrolled. The general data of patients were collected by self-made questionnaire, including gender, age, education experience, age at first episode, family history of mental diseases, disease duration, number of attack, working status and family status. Early trauma experience was assessed with early trauma experience inventory-short form, which involved four dimensions of common trauma, body trauma, emotional abuse and sexual abuse, and the scores of patients with depression and bipolar disorder were compared with nonparametric test. The correlation of different kinds of early trauma experience with depression and bipolar disorder was explored by Logistic regression analysis. Results The incidence of common trauma experience and total score of inventory in patients with bipolar disorder were significantly higher than those in patients with depression (P<0.05). In patients with depression, common trauma was related to family status （P<0.001）, body trauma was significantly related to gender, family status and working status （P＜0.05）, and emotional abuse was related to family status and number of attack （P<0.05）. In patients with bipolar disorder, common trauma was significantly related to family status and family history of metal diseases （P<0.05）, emotional abuse was significantly related to family status （P<0.01）, and sexual abuse was related to gender （P<0.01）. Conclusion Early trauma experience is correlated with both depression and bipolar disorder, and different kinds of trauma may play different roles in the onset and development of these two diseases.

Key words: early trauma, depression, bipolar disorder