上海交通大学学报（医学版）

›› 2012, Vol. 32 ›› Issue (2): 168-.doi: 10.3969/j.issn.1674-8115.2012.02.009

• 论著（临床研究） • 上一篇    下一篇

中国学龄儿童黄斑色素密度及与屈光状态和黄斑中心凹厚度的关系

郑文静1, 张正威1, 克里木江1, 朱剑锋2, 何鲜桂2, 柯碧莲1   

  1. 1.上海交通大学附属第一人民医院眼科, 上海 200080； 2.上海市眼病防治中心, 上海 200040
  • 出版日期:2012-02-28 发布日期:2012-02-28
  • 通讯作者: 柯碧莲, 电子信箱: kebilian@126.com。
  • 作者简介:郑文静（1987—）, 女, 硕士生；电子信箱: wenjing_zheng@139.com。
  • 基金资助:

    上海市自然科学基金（09ZR1425400）；上海市视觉复明中心课题基金（050802）；上海市眼底病重点实验室开放课题基金（07Z22911）

Macular pigment optical density and its relationship with refractive status and foveal thickness in Chinese school-aged children

ZHENG Wen-jing1, ZHANG Zheng-wei1, Kiram·Abla1, ZHU Jian-feng2, HE Xian-gui2, KE Bi-lian1   

  1. 1.Department of Ophthalmology, the First People's Hospital, Shanghai Jiaotong University, Shanghai 200080, China；2.Shanghai Eye Disease Prevention &|Treatment Center, Shanghai 200040, China
  • Online:2012-02-28 Published:2012-02-28
  • Supported by:

    Natural Science Foundation of Shanghai, 09ZR1425400；Foundation of Sight-Restoring Centre of Shanghai, 050802；Shanghai Key Laboratory for Ocular Fundus Diseases Foundation, 07Z22911

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摘要：

目的 研究中国学龄儿童黄斑色素密度（MPOD）及与屈光状态和黄斑中心凹厚度的关系。方法 选择上海市94名6～12岁健康儿童，异色闪烁光度仪法测量MPOD，光学相干断层扫描测量黄斑最小中心凹厚度 (MFT) 和中央中心凹厚度(CFT)，非接触性眼压计测量眼压(IOP)，扩瞳测量等效球镜（SE），计算体质量指数(BMI)；分析不同性别间MPOD的差异，MPOD与年龄、BMI、IOP、SE、MFT和CFT的关系，以及不同屈光状态下MPOD与MFT和CFT的关系。结果 受检儿童平均MPOD为0.56±0.25，男性与女性的MPOD比较差异无统计学意义（P＞0.05）。MOPD与年龄、BMI、IOP、SE、MFT和CFT无相关性（均P>0.05）。屈光度≤－0.5 D时，MPOD与MFT呈显著负相关（r=－0.66，P=0.028），与CFT呈显著正相关（r=0.67，P=0.025）。结论 中国6～12岁低、中度近视儿童MPOD与MFT呈负相关，与CFT呈正相关。

关键词: 黄斑色素密度, 屈光不正, 中心凹厚度, 中国儿童

Abstract:

Objective To investigate the macular pigment optical density (MPOD) and its relationship with refractive status and foveal thickness in Chinese school-aged children. Methods Ninety-four healthy children aged from 6 to 12 were recruited in Shanghai. MPOD was determined with heterochromatic flicker photometry, both minimum foveal thickness (MFT) and central foveal thickness (CFT) were measured by optical coherence tomography (OCT), and non-contact tonometer was used to measure intraocular pressure (IOP) followed by determination of spherical equivalent (SE) refraction after pupil dilation. Besides, body mass index (BMI) was obtained. The differences in MPOD between different genders were analysed, the correlation of MPOD with age, BMI, IOP, SE, MFT and CFT was explored, and the correlation of MPOD with MFT and CFT under different refractive status was determined. Results The mean MPOD in examined children was 0.56±0.25, with no significant difference between boys and girls (P＞0.05). There was no significant correlation of MOPD with age, BMI, IOP, SE, MFT and CFT (P>0.05 for all). In children with refractive diopter ≤－0.5 D, there was an inverse relationship between MPOD and MFT (r=－0.66，P=0.028) and a positive relationship between MPOD and CFT (r=0.67，P=0.025). Conclusion MPOD reversely correlates MFT and has a positive relationship with CFT in Chinese children aged from 6 to 12 with low to moderate myopia.

Key words: macular pigment optical density, refractive error, foveal thickness, Chinese children