上海交通大学学报（医学版）

›› 2012, Vol. 32 ›› Issue (2): 172-.doi: 10.3969/j.issn.1674-8115.2012.02.010

• 论著（临床研究） • 上一篇    下一篇

托吡卡胺所致的睫状肌麻痹对儿童眼前节参数的影响

张正威1, 克里木江1, 郑文静1, 朱剑锋2, 何鲜桂2, 柯碧莲1   

  1. 1.上海交通大学附属第一人民医院眼科, 上海 200080； 2.上海市眼病防治中心, 上海 200040
  • 出版日期:2012-02-28 发布日期:2012-02-28
  • 通讯作者: 柯碧莲, 电子信箱: kebilian@126.com。
  • 作者简介:张正威（1985—）, 男, 硕士生；电子信箱: weir2008@foxmail.com；克里木江（1982—）| 男, 维吾尔族, 硕士生；电子信箱: 58660417@qq.com。
  • 基金资助:

    上海市自然科学基金（09ZR1425400）；上海市视觉复明临床医学中心课题（050802）；上海市眼底病重点实验室开放课题基金（07Z22911）

Effect of cycloplegia induced by tropicamide on ocular anterior segment parameters in children

ZHANG Zheng-wei1, Kiram·Abla1, ZHENG Wen-jing1, ZHU Jian-feng2, HE Xian-gui2, KE Bi-lian1   

  1. 1.Department of Ophthalmology, the First People's Hospital, Shanghai Jiaotong University, Shanghai 200080, China；2.Shanghai Eye Diseases Prevention &|Treatment Center, Shanghai 200040, China
  • Online:2012-02-28 Published:2012-02-28
  • Supported by:

    Natural Science Foundation of Shanghai, 09ZR1425400；Foundation of Shanghai Clinical Medicine Center for Vision Rehabilitation,050802；Shanghai Key Laboratory for Ocular Fundus Diseases Foundation, 07Z22911

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摘要：

目的 研究0.5%托吡卡胺滴眼液所致的睫状肌麻痹前后儿童眼前节参数的变化。方法 选择309名健康儿童，0.5%托吡卡胺滴眼液滴眼麻痹睫状肌，睫状肌麻痹前后分别采用Pentacam系统测量眼前节参数。分析睫状肌麻痹前后眼前节参数的变化以及不同屈光状态和不同性别儿童睫状肌麻痹前后眼前节参数的变化。结果 294名儿童的检查结果符合纳入标准。睫状肌麻痹后，中央角膜厚度（CCT）、角膜容积（CV）、前房深度（ACD）和前房容量（ACV）显著大于睫状肌麻痹前（P<0.05或P<0.01），前房角(ACA)显著小于睫状肌麻痹前(P<0.05)。远视者睫状肌麻痹前后ACD差值显著大于正视者、低度近视者和中度近视者 (P<0.05)，远视者睫状肌麻痹前后ACV差值显著大于低度近视者和中度近视者（P<0.001）。男孩睫状肌麻痹后ACA显著小于睫状肌麻痹前（P<0.05），女孩睫状肌麻痹前后ACA差异无统计学意义（P>0.05）。结论 0.5%托吡卡胺滴眼液可导致儿童CCT、CV、ACD和ACV显著增加，ACA显著减小。

关键词: 眼前节, 托吡卡胺, 睫状肌麻痹, Pentacam系统

Abstract:

Objective To investigate the changes of ocular anterior segment parameters before and after cycloplegia induced by 0.5% tropicamide in children. Methods Three hundred and nine healthy children were selected, cycloplegia was induced by 0.5% tropicamide, and ocular anterior segment parameters were measured with Pentacam system before and after cycloplegia. The changes of ocular anterior segment parameters before and after cycloplegia were investigated, and those stratified by refractive status and genders were analysed. Results The data of 294 children met the inclusion criteria. The central corneal thickness (CCT), corneal volume (CV), anterior chamber depth (ACD) and anterior chamber volume (ACV) after cycloplegia were significantly larger than those before cycloplegia (P<0.05 or P<0.01), and the anterior chamber angle (ACA) after cycloplegia was significantly smaller than that before cycloplegia (P<0.05). The difference between ACD after cycloplegia and that before cycloplegia in children with hyperopia was significantly larger than those in children with emmetropia, low myopia and medium myopia (P<0.05), and the difference between ACV after cycloplegia and that before cycloplegia in children with hyperopia was significantly larger than those in children with low myopia and medium myopia (P<0.001). ACA after cycloplegia was significantly smaller than that before cycloplegia in boys (P<0.05), while ACA after cycloplegia was not different from that before cycloplegia in girls (P>0.05). Conclusion 0.5% tropicamide may cause significant increase in CCT, CV, ACD and ACV, and significant decrease in ACA in children.

Key words: ocular anterior segment, tropicamide, cycloplegia, Pentacam system