上海交通大学学报（医学版）

›› 2012, Vol. 32 ›› Issue (3): 356-.doi: 10.3969/j.issn.1674-8115.2012.03.026

• 综述 • 上一篇    下一篇

线粒体膜通透性转换孔结构与功能研究进展

冯 阳, 刘建军, 黄 钢   

  1. 上海交通大学医学院附属仁济医院核医学科, 上海 200127
  • 出版日期:2012-03-28 发布日期:2012-03-28
  • 通讯作者: 刘建军, 电子信箱: ljjsh@133sh.com。
  • 作者简介:冯 阳（1982—）, 女, 硕士生；电子信箱: fengyang19820303@163.com。
  • 基金资助:

    国家自然科学基金(30830038)

Research progress of structure and function of mitochondrial permeability transition pore

FENG Yang, LIU Jian-jun, HUANG Gang   

  1. Department of Nuclear Medicine, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China
  • Online:2012-03-28 Published:2012-03-28
  • Supported by:

    National Natural Science Foundation of China, 30830038

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摘要：

线粒体膜通透性变化在细胞凋亡或坏死中具有重要作用，线粒体膜通透性转换孔可影响线粒体膜通透性变化。目前对线粒体膜通透性转换孔的分子结构和功能尚不明确。文章对腺嘌呤核苷酸转位酶（ANT）、电压依赖性阴离子通道（VDAC）、亲环蛋白D（Cyp D）、磷酸盐载体（PiC）、Bcl2蛋白家族等可能参与线粒体膜通透性转换孔结构组成或功能调节的分子研究进展进行综述。

关键词: 线粒体膜通透性转换孔, 凋亡, 坏死

Abstract:

The change of mitochondrial permeability plays an important role in the apoptosis and necrosis of cells, and mitochondria permeability transition pore may influence the change of mitochondrial permeability. However, the molecular structure and function of mitochondria permeability transition pore are not clearly revealed. The research progress of molecules involved in structure composition and function regulation of mitochondria permeability transition pore, including adenine nucleotide translocase (ANT), voltage-dependent anion-selective channel (VDAC), cyclophilin D (Cyp D), phosphatic carrier (PiC) and Bcl-2 proteins is reviewed in this paper.

Key words: mitochondrial permeability transition pore, apoptosis, necrosis