上海交通大学学报（医学版）

›› 2012, Vol. 32 ›› Issue (4): 393-.doi: 10.3969/j.issn.1674-8115.2012.04.004

• 专题报道（排尿功能障碍及盆底重建） • 上一篇    下一篇

血清松弛素浓度与女性盆底器官脱垂关系的研究

周艳娜1, 吴氢凯2, 程 慧2, 滕银成2   

  1. 1.上海交通大学附属第六人民医院金山分院妇产科, 上海 201500； 2.上海交通大学附属第六人民医院妇产科, 上海 200233
  • 出版日期:2012-04-28 发布日期:2012-04-27
  • 通讯作者: 吴氢凯, 电子信箱: angelh2@163.com。
  • 作者简介:周艳娜（1980—）, 女, 主治医师, 硕士；电子信箱: yuyang@mail.dhu.edu.cn。
  • 基金资助:

    上海市卫生局科研基金（2006057）

Relationship between serum relaxin levels and female pelvic floor prolapse

ZHOU Yan-na1, WU Qing-kai2, CHENG Hui2, TENG Yin-cheng2   

  1. 1.Department of Obstetrics and Gynecology, Jinshan Branch, the Sixth People's Hospital, Shanghai Jiaotong University, Shanghai 201500, China；2.Department of Obstetrics and Gynecology, the Sixth People's Hospital, Shanghai Jiaotong University, Shanghai 200233, China
  • Online:2012-04-28 Published:2012-04-27
  • Supported by:

    Shanghai Municipal Health Bureau Foundation, 2006057

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摘要：

目的 研究血清松弛素浓度与女性盆底器官脱垂（POP）及绝经的关系。方法 选择POP患者39例（POP组），另设盆底功能正常的39名妇女为对照组；分析POP与血清松弛素水平的关系以及绝经对血清松弛素水平的影响。结果 POP组的血清松弛素质量浓度为（406.7±311.2）ng/L，对照组为（199.4±208.7）ng/L，差异有统计学意义(P<0.05)；绝经后妇女的血清松弛素质量浓度为（172.0±197.5）ng/L，未绝经妇女为（587.5±716.8）ng/L，差异有统计学意义(P<0.05)；POP组中已绝经患者的血清松弛素质量浓度为（226.2±178.8）ng/L，对照组中已绝经妇女（108.4±98.7）ng/L，差异有统计学意义(P<0.05)；POP组中未绝经患者的血清松弛素质量浓度为（1870.2±264.4） ng/L，对照组中未绝经妇女为（373.7±370.4）ng/L，差异具有统计学意义(P<0.001)。结论 血清松弛素水平升高可能是妇女发生POP的病因。

关键词: 女性盆底器官脱垂, 血清松弛素, 绝经

Abstract:

Objective To investigate the correlation of serum relaxin level with female pelvic organ prolapse (POP) and menopause. Methods Thirty-nine patients with POP (POP group) were selected, and another 39 women with normal pelvic floor function were served as control group. The relationship between POP and serum relaxin level was analysed, and the effect of menopause on serum relaxin level was investigated. Results The mass concentrations of serum relaxin in POP group and control group were (406.7±311.2) ng/L and (199.4±208.7) ng/L respectively, and there were significant differences between two groups (P<0.05). The mass concentrations of serum relaxin of menopausal women and non-menopausal women were (172.0±197.5) ng/L and (587.5±716.8) ng/L respectively, and there were significant differences between two groups (P<0.05). The mass concentrations of serum relaxin of menopausal women in POP group and in control group were (226.2±178.8) and (108.4±98.7) ng/L respectively, and there were significant differences between two groups (P<0.05). The mass concentrations of serum relaxin of non-menopausal women in POP group and in control group were (1870.2±264.4) ng/L and (373.7±370.4) ng/L respectively, and there were significant differences between two groups (P<0.001). Conclusion The elevation of serum relaxin level may be the cause of female POP.

Key words: female pelvic organ prolapse, serum relaxin, menopause