上海交通大学学报（医学版）

›› 2012, Vol. 32 ›› Issue (4): 508-.doi: 10.3969/j.issn.1674-8115.2012.04.029

• 论著（预防医学） • 上一篇    下一篇

我国四川、广西、新疆地区女性性工作者对暴露前预防用药预防HIV感染接受意愿调查

邱 蕾1, 田考聪1, 钟晓妮1, 张 燕1, 彭 斌1, 梁 浩2, 邹云锋3, 罗锦昆4, 彭鸿斌4, 黄爱龙5   

  1. 1.重庆医科大学公共卫生学院卫生统计学教研室, 重庆 400016； 2.广西医科大学公共卫生学院流行病与卫生统计学教研室, 南宁 530021； 3.广西医科大学公共卫生学院毒理学教研室, 南宁 530021； 4.四川省南充市顺庆区疾病预防控制中心, 南充 637000； 5.重庆医科大学感染性疾病分子生物学教育部重点实验室, 重庆 400016
  • 出版日期:2012-04-28 发布日期:2012-04-27
  • 通讯作者: 田考聪, 电子信箱: tkc5155@126.com；钟晓妮, 电子信箱: zxn66@vip.sina.com。
  • 作者简介:邱 蕾（1988—）, 女, 硕士生；电子信箱: qiulei2010@sina.com。
  • 基金资助:

    国家科技重大专项项目(2008ZX10001-016)

Investigation on acceptability of pre-exposure prophylaxis among female sex workers in Sichuan, Xinjiang and Guangxi of China

QIU Lei1, TIAN Kao-cong1, ZHONG Xiao-ni1, ZHANG Yan1, PENG Bin1, LIANG Hao2, ZOU Yun-feng3, LUO Jin-kun4, PENG Hong-bin4, HUANG Ai-long5   

  1. 1. Department of Medical Statistics, School of Public Health, Chongqing Medical University, Chongqing 400016, China；2.Department of Epidemiology and Medical Statistics, School of Public Health, Guangxi Medical University, Nanning 530021, China；3.Department of Toxicology, School of Public Health, Guangxi Medical University, Nanning 530021, China；4.Sichuan Nanchong Shunqing District Center of Disease Control and Prevention, Nanchong 637000, China；5.Key Laboratory of Molecular Biology for Infectious Diseases of Ministry of Education, Chongqing Medical University, Chongqing 400016, China
  • Online:2012-04-28 Published:2012-04-27
  • Supported by:

    National Major Science and Technology Program, 2008ZX10001-016

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摘要：

目的 了解我国四川省、新疆维吾尔自治区、广西壮族自治区女性性工作者（FSWs）对暴露前预防用药(Pr-EP)预防人类免疫缺陷病毒(HIV)感染的接受意愿及其影响因素。方法 采用问卷调查的形式，调查对象为四川省、新疆维吾尔自治区、广西壮族自治区的FSWs。调查完成问卷1 478份，有效问卷1 469份（占99.39%）。调查内容主要为FSWs对Pr-EP的知晓情况和接受意愿。结果 经调查人员介绍了Pr-EP相关知识后，在Pr-EP安全有效的前提下，共有801人（54.5%）表示“肯定愿意使用”，有196人（13.3%）表示“可能会使用”，Pr-EP使用意愿为67.9%（997/1469），三个地区间的差异无统计学意义(P>0.05)。经过单因素χ2检验和Logistic回归分析，结果显示：Pr-EP的接受意愿的影响因素包括危险自评(OR=1.776，P=0.005)、性服务安全套使用(OR=1.346，P=0.000)、最近三次发生性交易使用安全套的频率(OR=1.519，P=0.003)、是否使用过药物预防性病(OR=1.185，P=0.025)、是否拒绝与不使用安全套的人发生性行为(OR=1.479，P=0.009)、是否会建议朋友接受Pr-EP(OR=5.618，P=0.000)。三个地区FSWs对Pr-EP比较关注的是其安全性/不良反应、效果/有效性、费用。结论 坚持使用安全套的FSWs更倾向于接受Pr-EP；应该加大Pr-EP相关知识的宣传力度，提高FSWs对Pr-EP知晓率，进一步提高FSWs对于Pr-EP的接受意愿；同伴教育可能是推广Pr-EP的有效方式。

关键词: 人类免疫缺陷病毒, 女性性工作者, 暴露前预防用药, 接受意愿

Abstract:

Objective To investigate the acceptability and influencing factors of pre-exposure prophylaxis (Pr-EP) for human immunodeficiency virus (HIV) among female sex workers (FSWs) in Sichuan, Xinjiang and Guangxi of China. Methods FSWs selected from Sichuan, Xinjiang and Guangxi were surveyed with questionnaires. A total of 1 478 questionnaires were completed, among which 1 469 (99.39%) were effective. The survey mainly concerned with the awareness and acceptability of FSWs on Pr-EP. Results After introduction to Pr-EP by the investigators, under the precondition that Pr-EP was effective and safe, 997(67.9%) FSWs accepted Pr-EP, and there was no significant difference in the acceptability among FSWs in three regions (P>0.05). Univariate χ2 analysis and Logistic regression analysis revealed that self-evaluation of risks (OR=1.776, P=0.005), regular condom use in sex service (OR=1.346, P=0.000), frequency of condom use during the latest three times of sex service (OR=1.519, P=0.003), drug use to prevent sexually-transmitted disease (OR=1.185, P=0.025), refusal of having sex with those without condom use (OR=1.479, P=0.009) and advising peers to use Pr-EP (OR=5.618, P=0.000) were influencing factors of acceptability of Pr-EP. FSWs mainly concerned of the security, effectiveness and cost of Pr-EP. Conclusion FSWs with regular condom use are more likely to accept Pr-EP. Pr-EP related knowledge should be well exposed among FSWs to increase the awareness and acceptability. Peer education may be a better way to improve the acceptability of Pr-EP.

Key words: human immunodeficiency virus, female sex worker, pre-exposure prophylaxis, acceptability