上海交通大学学报（医学版）

›› 2012, Vol. 32 ›› Issue (5): 661-.doi: 10.3969/j.issn.1674-8115.2012.05.029

• 综述 • 上一篇    下一篇

结核分枝杆菌最低抑菌浓度测定方法及临界值设置研究进展

张朝宝1,3, 王洪海2, 张舒林1   

  1. 1.上海交通大学 基础医学院病原生物学教研室, 上海 200025； 2.复旦大学遗传学研究所 遗传工程国家重点实验室, 上海 200433； 3.武汉工业学院生物与制药工程学院, 武汉 430023
  • 出版日期:2012-05-28 发布日期:2012-06-01
  • 通讯作者: 张舒林, 电子信箱: shulinzhang@sjtu.edu.cn。
  • 作者简介:张朝宝（1986—）, 男, 硕士生；电子信箱: moyuanmoyuan@163.com。
  • 基金资助:

    “十一五”国家科技重大专项（2009ZX10003-017和2009ZX10004-313）

Research progress of minimum inhibitory concentration detection technology and breakpoint setting for Mycobacterium tuberculosis

ZHANG Chao-bao1,3, WANG Hong-hai2, ZHANG Shu-lin1   

  1. 1.Department of Medical Microbiology, Basic Medical College, Shanghai Jiaotong University, Shanghai 200025, China；2.State Key Laboratory of Genetic Engineering, Institute of Genetics, Fudan University, Shanghai 200433, China；3.School of Biology and Pharmaceutical Engineering, Wuhan Polytechnic University, Wuhan 430023, China
  • Online:2012-05-28 Published:2012-06-01
  • Supported by:

    National Major Science and Technology Project of China in the “Eleventh Five-year Plan”, 2009ZX10003-017, 2009ZX10004-313

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摘要：

结核病迄今仍是全球单一病原体引起死亡人数最多的传染性疾病。耐药及耐多药的产生是结核病流行和广泛传播的重要原因之一。建立规范、有效的结核分枝杆菌药敏最低抑菌浓度（MIC）的检测方法及设置有效的临界值对于结核病个体化治疗、快速耐药检测方法的研究以及新型抗结核药物筛选等领域具有重要意义，也是控制耐药结核病产生和传播的关键。该文就结核分枝杆菌MIC测定方法及临界值设置等方面的研究进展进行综述。

关键词: 结核分枝杆菌, 最低抑菌浓度, 临界值

Abstract:

Tuberculosis is the most common cause of death due to a single infectious agent. The emergence of drug resistance and multidrug resistance is one of the important causes for the epidemics and widespreading of tuberculosis. It is of vital importance to develop the standard and effective detection approach of minimum inhibitory concentration (MIC) and to set up the effective breakpoints in the fields of individualized treatment, detection of drug resistance and drug screening for tuberculosis. The research progress of MIC detection technology and breakpoints setting for Mycobacterium tuberculosis are reviewed in this paper.

Key words: Mycobacterium tuberculosis, minimum inhibitor concentration, breakpoint