上海交通大学学报（医学版）

›› 2012, Vol. 32 ›› Issue (5): 667-.doi: 10.3969/j.issn.1674-8115.2012.05.030

• 综述 • 上一篇    下一篇

诱导多能干细胞在肝脏疾病中的研究进展

孙 超, 范建高   

  1. 上海交通大学 医学院附属新华医院消化内科, 上海 200092
  • 出版日期:2012-05-28 发布日期:2012-06-01
  • 作者简介:孙 超（1976—）, 女, 主治医师, 博士生；电子信箱: csun7682@yahoo.com.cn。
  • 基金资助:

    国家自然科学基金（81000173）

Research progress of induced pluripotent stem cells in liver diseases

SUN Chao, FAN Jian-gao   

  1. Department of Gastroenterology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China
  • Online:2012-05-28 Published:2012-06-01
  • Supported by:

    National Natural Science Foundation of China, 81000173

PDF (PC)

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摘要：

干细胞，特别是诱导多能干细胞（iPS细胞）可分化为有功能的肝细胞，同时避开了胚胎干细胞的伦理问题，为终末期肝病的替代治疗提供了新的种子细胞。文章对iPS细胞在肝脏疾病研究中的实验方法、研究结果以及临床应用前景予以阐述，为iPS细胞在肝病治疗方面的实验和临床应用提供借鉴。

关键词: 诱导多能干细胞, 肝脏疾病, 肝系细胞, 细胞移植

Abstract:

Stem cells, especially induced pluripotent stem cells (iPS cells), could differentiate into functional hepatocytes and avoid the ethical issues in the application of embryonic stem cells. Therefore, stem cells may serve as new seed cells for the replacement therapy for end-stage hepatic diseases. The experimental methods, research findings and clinical prospects of iPS cells in liver diseases are introduced in this paper, in hopes of providing references for the basic research and clinical practice of treatment of liver diseases.

Key words: induced pluripotent stem cells, liver diseases, hepatic lineage, cell transplantation