›› 2012, Vol. 32 ›› Issue (5): 667-.doi: 10.3969/j.issn.1674-8115.2012.05.030

• 综述 • 上一篇    下一篇


孙 超, 范建高   

  1. 上海交通大学 医学院附属新华医院消化内科, 上海 200092
  • 出版日期:2012-05-28 发布日期:2012-06-01
  • 作者简介:孙 超(1976—), 女, 主治医师, 博士生;电子信箱: csun7682@yahoo.com.cn。
  • 基金资助:


Research progress of induced pluripotent stem cells in liver diseases

SUN Chao, FAN Jian-gao   

  1. Department of Gastroenterology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China
  • Online:2012-05-28 Published:2012-06-01
  • Supported by:

    National Natural Science Foundation of China, 81000173



关键词: 诱导多能干细胞, 肝脏疾病, 肝系细胞, 细胞移植


Stem cells, especially induced pluripotent stem cells (iPS cells), could differentiate into functional hepatocytes and avoid the ethical issues in the application of embryonic stem cells. Therefore, stem cells may serve as new seed cells for the replacement therapy for end-stage hepatic diseases. The experimental methods, research findings and clinical prospects of iPS cells in liver diseases are introduced in this paper, in hopes of providing references for the basic research and clinical practice of treatment of liver diseases.

Key words: induced pluripotent stem cells, liver diseases, hepatic lineage, cell transplantation