上海交通大学学报（医学版）

›› 2012, Vol. 32 ›› Issue (9): 1254-.doi: 10.3969/j.issn.1674-8115.2012.09.024

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瘢痕、血管瘤和淋巴水肿研究和治疗进展

刘 伟, 林晓曦, 刘宁飞   

  1. 上海交通大学 医学院附属第九人民医院整复外科, 上海 200011
  • 出版日期:2012-09-28 发布日期:2012-09-29
  • 作者简介:刘伟（1960—）, 男, 教授, 博士, 博士生导师, 现任上海市整复外科研究所副所长、上海市组织工程重点实验室副主任和上海交通大学医学院上海干细胞研究所副主任；电子信箱: liuwei_md@yahoo.com.cn。
  • 基金资助:

    国家自然科学基金(31170937, 81171827, 81071578, 81071590, 30872694)；教育部新世纪优秀人才计划（ncet-08-0354）；卫生部行业基金项目（200802097）

Progress of diagnosis and treatment in scarring, vascular anomalies and lymphedema

LIU Wei, LIN Xiao-xi, LIU Ning-fei   

  1. Department of Plastic Surgery, the Ninth People´s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, China
  • Online:2012-09-28 Published:2012-09-29

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摘要：

瘢痕、血管瘤和肢体淋巴水肿是整形外科领域的常见病和难治性疾病，具有较高的发病率，严重影响患者的身心健康。因此，进一步明确疾病的发病机制、提高疾病的诊断效率和治疗技术的创新一直是这一领域关注的重点。本课题组在相关领域的研究中取得以下进展：①阐述了病理性干细胞、耐药性和生长分化因子-9（GDF9）差异表达在瘢痕疙瘩中的发病机制；②建立了低浓度化学药物瘢痕疙瘩治疗体系，显著提高治愈率和降低复发率；③建立了组织工程皮肤促进创面愈合、减少瘢痕形成的方法；④建立了婴幼儿血管瘤诊断与治疗体系；⑤建立了葡萄酒色斑的临床分类；⑥建立了静脉畸形的诊断和治疗体系；⑦建立了动静脉畸形的诊断和治疗体系；⑧初步阐明了炎性淋巴管生长的分子机制；⑨建立了肢体淋巴水肿动态核磁共振淋巴造影诊断体系；⑩开发了淋巴水肿治疗中药。

关键词: 瘢痕, 血管瘤, 肢体淋巴水肿

Abstract:

Scar, vascular anomalies and lymphedema are the common diseases that are difficult to treat, which severely affect patients´ psychological and physical fitness. Therefore, further defining the disease mechanism and improving the diagnosis and therapeutic efficiency are the important topics of this area. In this project, our group has: ①revealed the role of keloid stem cells, drug resistance and GDF-9 differentiation in keloid development; ②established low dose chemotherapy of keloid with increased cure rate and reduced recurrence rate; ③established engineered epidermis to treat wound bed to inhibit scar formation; ④established diagnosis and therapy system in infantile hemangioma; ⑤established clinical classification of port wine stains; ⑥established diagnosis and therapy of venous malformations; ⑦established diagnosis and therapy methods for arteriovenous malformations; ⑧preliminarily defined the molecular mechanism of lymphedema; ⑨established MRI diagnosis for lymphedema; ⑩development of specialized traditional Chinese medicine for lymphedema.

Key words: scarring, hemangioma, lymphedema