上海交通大学学报（医学版）

›› 2012, Vol. 32 ›› Issue (11): 1401-.doi: 10.3969/j.issn.1674-8115.2012.11.001

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后抗生素时代我们如何征服细菌？

郭晓奎   

  1. 上海交通大学 基础医学院病原生物学教研室, 上海 200025
  • 出版日期:2012-11-28 发布日期:2012-11-30
  • 作者简介:郭晓奎(1964—), 男, 教授, 博士, 博士生导师；电子信箱: microbiology@sjtu.edu.cn。
  • 基金资助:

    国家高技术研究发展计划（“八六三”计划）（2011AA02A119）

How to conquer bacteria in post-antibiotic era?

GUO Xiao-kui   

  1. Department of Medical Microbiology and Parasitology, Basic Medical College, Shanghai Jiaotong University, Shanghai 200025, China
  • Online:2012-11-28 Published:2012-11-30
  • Supported by:

    National High Technology Research and Development Program of China, 2011AA02A119

PDF (PC)

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摘要：

耐药性“超级细菌”的出现，将使我们重新步入无抗生素可用的时代，即“后抗生素时代”。面对日益严重的细菌耐药性，寻找新的抗菌药物及治疗方案已成为目前急需解决的难题。文章阐述新型抗生素、抗菌肽、噬菌体和中药制剂的研究开发及应用前景，为后抗生素时代针对耐药细菌，特别是超级细菌的抗感染药物的研究提供思路。

关键词: 耐药, 细菌, 控制

Abstract:

The occurrence of antibiotic resistant bacteria, especially pan-drug resistant bacteria may make no antibiotics available for the treatment of infectious diseases, which will lead to the emerge of post-antibiotic era. It is imperative to find new antibacterial drugs or strategies to solve the increasingly serious problem of drug resistance. The invention status and application prospect of newtype antibiotics, antimicrobial peptide, bacteriophage and traditional Chinese medicine preparation are introduced in this paper, which may provide reference for the exploration of antibacterial drugs to conquer bacteria in post-antibiotic era.

Key words: drug resistant, bacteria, control