上海交通大学学报（医学版）

›› 2013, Vol. 33 ›› Issue (3): 359-.doi: 10.3969/j.issn.1674-8115.2013.03.021

• 综述 • 上一篇    下一篇

睡眠时间不足致脂肪细胞因子分泌紊乱与肥胖相关性的研究进展

陈 婷1, 张泽彧1, 陈 喆1, 陈 炉1, 杨 倩1, 戴 斐2, 李生慧2, 郑志杰2   

  1. 1.上海交通大学2010级预防医学本科, 上海 200025； 2.上海交通大学 公共卫生学院预防医学教研室, 上海 200025
  • 出版日期:2013-03-28 发布日期:2013-03-29
  • 通讯作者: 李生慧, 电子信箱: lsh9907@163.com； 郑志杰, 电子信箱: zheng22762@live.com。
  • 作者简介:陈 婷（1991—）, 女, 本科生； 电子信箱: t.chen88@163.com； 张泽彧（1991—）, 女, 本科生； 电子信箱: v_sapphira@163.com。
  • 基金资助:

    国家自然科学基金(81072314, 30700670)；上海市教委科研创新项目（13YZ034）；上海交通大学医学院“新百人计划”；上海市公共卫生优秀学科带头人培养计划（GWDTR201222)

Research progress of relationship between obesity and adipocytokine secretion disorder induced by short sleep duration

CHEN Ting1, ZHANG Ze-yu1, CHEN Zhe1, CHEN Lu1, YANG Qian1, DAI Fei2, LI Sheng-hui2, ZHENG Zhi-jie2   

  1. 1.Grade 2010 of Preventive Medicine Undergraduate Program, Shanghai Jiaotong University, Shanghai 200025, China； 2.Department of Preventive Medicine, School of Public Heath, Shanghai Jiaotong University, Shanghai 200025, China
  • Online:2013-03-28 Published:2013-03-29
  • Supported by:

    National Natural Science Foundation of China, 81072314, 30700670； Shanghai Education Committee Foundation, 13YZ034； Shanghai Jiaotong University School of Medicine Foundation； Leading Scholar of Excellent Discipline of Public Health of Shanghai, GWDTR201222

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摘要：

睡眠时间不足与肥胖作为重要的健康问题日益受到关注。最新研究资料提示，睡眠时间可能是肥胖发生和发展的重要影响因素。睡眠时间不足者，其体内多种脂肪细胞因子(瘦素、脂联素和内脂素等)的分泌量、分泌节律及其之间的动态平衡发生紊乱，进而可引发肥胖和胰岛素抵抗。文章以脂肪细胞因子为观察视角，对目前国内外关于睡眠时间不足与肥胖相关的机制研究进展作一概述，探讨多种脂肪细胞因子在睡眠和肥胖发生和发展中的作用。

关键词: 肥胖, 睡眠, 脂肪细胞因子

Abstract:

Both short sleep duration and obesity are global concerns threatening human health. Recent research data have indicated that sleep duration is an important influential factor for obesity. Short sleep duration disturbs the secretory volume and rhythm of adipocytokines such as leptin, adiponectin and visfatin, and interrupts the dynamic balance between them, after which obesity and insulin resistance may be triggered. This paper is to systematically review the existing domestic and international literatures on the related mechanisms between short sleep duration and obesity, and discuss the effect of several important adipocytokines on sleep and obesity.

Key words: obesity, sleep, adipocytokine