上海交通大学学报（医学版）

›› 2013, Vol. 33 ›› Issue (3): 363-.doi: 10.3969/j.issn.1674-8115.2013.03.022

• 综述 • 上一篇    下一篇

远程缺血处理的临床应用进展

冯肖肖, 周丽佳, 吴建永   

  1. 浙江大学 医学院附属第一医院肾脏病中心, 浙江 310006
  • 出版日期:2013-03-28 发布日期:2013-03-29
  • 通讯作者: 吴建永, 电子信箱：wujianyong@medmail.com.cn。
  • 作者简介:冯肖肖（1988—）, 女, 硕士生； 电子信箱: xiaoeq1010@163.com。

Clinical application of remote ischemic conditioning

FENG Xiao-xiao, ZHOU Li-jia, WU Jian-yong   

  1. Kidney Disease Center, the First Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang 310006, China
  • Online:2013-03-28 Published:2013-03-29

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摘要：

缺血再灌注损伤（IRI）是临床上一种常见的病理生理变化，其损伤程度直接关系到疾病的治疗效果。研究发现：给予远距离组织（上肢或下肢）多次短暂、重复缺血再灌注，即远程缺血处理（RIC）可减轻重要器官长时间持续缺血所导致的IRI；在心脏手术、血管手术和冠状动脉介入术中给予RIC能减轻IRI的程度；RIC无创、安全、简单且经济，为治疗缺血性疾病提供了一种新的方法和思路，具有广阔的临床应用前景。

关键词: 远程缺血处理, 缺血再灌注损伤, 临床应用

Abstract:

Ischemic reperfusion injury (IRI) is a common clinical pathophysiology, and the severity of IRI correlates with the therapeutic effects of the diseases. Remote ischemic conditioning (RIC) is induced by several periods of ischemia on tissues (upper or lower limb) to produce systemic protection against IRI in distant organs. More studies confirm that RIC can reduce IRI in cardiac surgery, vascular surgery and elective percutaneous coronary intervention. RIC is non-invasive, safe, convenient and economical, which provides a new idea and method to treat IRI and has a promising prospect in clinical application.

Key words: remote ischemic conditioning, ischemic reperfusion injury, clinical application