抑郁症作为常见精神障碍，给患者造成了极大的负担。目前，人们对抑郁症遗传机制的理解远不如精神分裂症、双相障碍等其他常见精神障碍透彻。近年来，随着临床样本量的不断积累以及研究方法与技术的进步，抑郁症的遗传学研究取得了一定的进展。该文从抑郁症的候选基因、常见变异位点、罕见变异位点以及染色体结构变异等方面对该病的遗传学研究进展作一综述。

Depression is a common mental disorder and causes great disease burden. To date peoples understanding of genetic mechanisms of depression is lagging far behind that of other psychiatric disorders such as schizophrenia and bipolar disorder. Recently, with the accumulation of clinical samples and the advances of methodology and technology, certain progress in genetics of depression has been made. This review summarizes the genetic research progress in candidate genes, common variants, rare variants and chromosome structure variations of depression.