上海交通大学学报（医学版）

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2019 , Vol. 39 >Issue 9: 1095

DOI: https://doi.org/10.3969/j.issn.1674-8115.2019.09.025

综述

抗 N-甲基-D-天冬氨酸受体脑炎发病机制及临床研究进展

  • 倪优 ,
  • 陈晟
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  • 上海交通大学医学院附属瑞金医院神经内科，上海 200025
倪优（1996—），女，硕士生；电子信箱： niyou96@Foxmail.com。

网络出版日期: 2019-11-02

基金资助

国家自然科学基金面上项目（81671241）；上海市曙光学者计划（18SG15）；上海市教育委员会高峰高原学科建设计划（20181802）

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Advances of pathogenesis and clinical research in anti-N-methyl-D-aspartate receptor encephalitis

  • NI You ,
  • CHEN Sheng
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  • Department of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

Online published: 2019-11-02

Supported by

National Natural Science Foundation of China, 81671241; Shanghai Shuguang Scholar Project, 18SG15; Shanghai Municipal Education Commission— Gaofeng Clinical Medicine Support, 20181802）。

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摘要

抗 N-甲基 -D-天冬氨酸受体（ N-methyl-D-aspartate receptor，NMDAR）脑炎，是一种由抗 NMDAR抗体介导的自身免疫性脑炎。该病好发于年轻女性患者，部分患者可伴肿瘤。该病的诊断主要依赖脑脊液及血清 NMDAR抗体检测，早期肿瘤切除和免疫治疗后多数患者预后较好。文章从发病机制、基因特征、临床特点、治疗预后等方面总结了该病目前的研究进展。

关键词： 抗 N-甲基 -D-天冬氨酸受体脑炎; 自身免疫性脑炎; 发病机制; 临床特点; 基因

本文引用格式

倪优 , 陈晟 . 抗 N-甲基-D-天冬氨酸受体脑炎发病机制及临床研究进展[J]. 上海交通大学学报（医学版）, 2019 , 39(9) : 1095 . DOI: 10.3969/j.issn.1674-8115.2019.09.025

Abstract

Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is one kind of autoimmune encephalitis that is mediatedNMDAR antibodies. Most of the patients are young women and some of them may suffer tumors. Diagnosis is mainly based on identification of NMDAR antibodies in cerebrospinal fluid and serum. Most patients can recover after removal of the tumor or through immunotherapy. This article reviews some viewpoints of pathogenesis, genetic features, clinical characteristics, treatment and prognosis of the disease.

Key words： anti-N-methyl-D-aspartate receptor encephalitis; autoimmune encephalitis; pathogenesis; clinical feature; gene

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