上海交通大学学报（医学版）

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2020 , Vol. 40 >Issue 1: 123

DOI: https://doi.org/10.3969/j.issn.1674-8115.2020.01.020

综述

单核 - 巨噬细胞在抗中性粒细胞胞浆抗体相关性血管炎中作用的研究进展

  • 安晓宁 ,
  • 陈永熙
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  • 上海交通大学医学院附属瑞金医院肾内科,上海 200025
安晓宁（1994—），女，硕士生；电子信箱：anxiaoning@sjtu.edu.cn。

网络出版日期: 2020-03-05

基金资助

国家自然科学基金（81470041，81000285）。

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Recent advances in role of monocyte-macrophage in anti-neutrophil cytoplasmic antibody associated vasculitis

  • AN Xiao-ning ,
  • CHEN Yong-xi
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  • Department of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

Online published: 2020-03-05

Supported by

National Natural Science Foundation of China (81470041, 81000285).

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摘要

抗中性粒细胞胞浆抗体（anti-neutrophil cytoplasmic antibody，ANCA）相关性血管炎（ANCA associated vasculitis，AAV）是一类全身性自身免疫性疾病。AAV以小血管壁的炎症或纤维素样坏死为病理基础，可累及多个器官系统，严重时可危及生命。单核 - 巨噬细胞是机体固有免疫系统中重要的细胞组分，包括血液中的单核细胞和组织中固定或游走的巨噬细胞。在不同组织器官中的单核 - 巨噬细胞参与AAV发病和疾病进展。文章就单核 - 巨噬细胞在AAV中的研究进展予以综述。

关键词： 抗中性粒细胞胞浆抗体; 抗中性粒细胞胞浆抗体相关性血管炎; 单核细胞; 巨噬细胞

本文引用格式

安晓宁 , 陈永熙 . 单核 - 巨噬细胞在抗中性粒细胞胞浆抗体相关性血管炎中作用的研究进展[J]. 上海交通大学学报（医学版）, 2020 , 40(1) : 123 . DOI: 10.3969/j.issn.1674-8115.2020.01.020

Abstract

Anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV) constitues a group of autoimmune diseases with poor prognosis. Inflammation and fibrinoid necrosis of the small vessels are the pathological features of the disease, and many organs and systems can be involved. Monocyte-macrophages are important to innate immune system. Monocyte-macrophage can respond rapidly to inflammation and participate in the progression of AAV. Recently, the role of monocyte-macrophage in AAV has been studied with great detail. This article reviews recent research progress of monocyte-macrophage in AAV so as to further understand the disease.

Key words： anti-neutrophil cytoplasmic antibody (ANCA); ANCA associated vasculitis; monocyte; macrophage

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