上海交通大学学报（医学版）

上海交通大学学报（医学版） >

2020 , Vol. 40 >Issue 1: 134

DOI: https://doi.org/10.3969/j.issn.1674-8115.2020.01.022

综述

干细胞来源的细胞外囊泡修复治疗中枢神经系统疾病的研究进展

  • 何征晖1 ,
  • 汪 泱2 ,
  • 邓志锋3
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  • 1. 上海交通大学附属第六人民医院临床医学院，上海 200233；2. 上海交通大学附属第六人民医院四肢显微外科研究所，上海 200233；3.上海交通大学附属第六人民医院神经外科，上海 200233
何征晖（1995—），男，本科生；电子信箱：hezhenghui8@qq.com。

网络出版日期: 2020-03-05

基金资助

国家自然科学基金（81671209）。

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Recent advances in using of stem cell-derived extracellular vesicles in treating central nervous system diseases

  • HE Zheng-hui ,
  • WANG Yang ,
  • DENG Zhi-feng
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  • 1. School of Clinical Medicine, Shanghai Sixth Peoples Hospital, Shanghai Jiao Tong University, Shanghai 200233, China; 2.Institute of Microsurgery on Extremities, Shanghai Sixth Peoples Hospital, Shanghai Jiao Tong University, Shanghai 200233, China; 3. Department of Neurosurgery, Shanghai Sixth Peoples Hospital Shanghai Jiao Tong University, Shanghai 200233, China

Online published: 2020-03-05

Supported by

National Natural Science Foundation of China (81671209).

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摘要

干细胞来源的细胞外囊泡（stem cell-derived extracellular vesicles，SC-EVs）能够调节病变细胞功能及微环境，且不具有干细胞移植的风险，能更安全地用于疾病治疗。在中枢神经系统损伤病灶中，SC-EVs能够促进神经血管再生并抑制炎症损伤，有利于神经功能康复。SC-EVs可减少Aβ蛋白相关的神经损伤，缓解阿尔茨海默病。SC-EVs还可以作为微RNA及化疗药物的运输载体治疗神经胶质瘤。该文就SC-EVs在中枢神经系统疾病治疗中应用的研究成果进行综述。

关键词： 干细胞来源的细胞外囊泡; 中枢神经系统损伤; 阿尔茨海默病; 神经胶质瘤

本文引用格式

何征晖1 , 汪 泱2 , 邓志锋3 . 干细胞来源的细胞外囊泡修复治疗中枢神经系统疾病的研究进展[J]. 上海交通大学学报（医学版）, 2020 , 40(1) : 134 . DOI: 10.3969/j.issn.1674-8115.2020.01.022

Abstract

Stem cell-derived extracellular vesicles can regulate functions of targeting cells in lesions and have fewer risks in treating diseases. In central nervous injury lesions, stem cell-derived extracellular vesicles can promote neurogenesis and angiogenesis and regulate nervous inflammation, which promotes the recovery of the nerve injury. Stem cell-derived extracellular vesicles can ease Aβ protein-related neuron damage in Alzheimers disease. Stem cell-derived extracellular vesicles also can deliver microRNA and chemotherapeutic agents to neuroglioma cells. This review introduces recent advances in using stem cell-derived extracellular vesicles in treating central nervous system diseases.

Key words： stem cell-derived extracellular vesicles (SC-EVs); central nervous system injury; Alzheimer’s disease; neuroglioma

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