目的·探索精神分裂症快感缺失的临床特征及其相关的影响因素。方法·2018年12月至2019年12月期间纳入71名精神分裂症患者及50名健康志愿者，使用阳性和阴性症状量表（Positive and Negative Syndrome Scale，PANSS）评估患者的精神症状，使用时间性愉快体验量表（Temporal Experience of Pleasure Scale，TEPS）和重复性成套神经心理状态测验（Repeatable Battery for the Assessment of Neuropsychological Status，RBANS）分别评估被试的快感缺失和认知功能。结果·TEPS评估结果显示，精神分裂症的期待性快感和消费性快感得分均低于健康对照（P=0.000）。逐步线性回归结果显示PANSS中的阴性症状得分（B=-0.895，P=0.002）和RBANS五因子中的延迟记忆得分（B=0.265，P=0.001）与精神分裂症快感缺失有关。结论·精神分裂症患者存在期待性和消费性快感缺失，而精神分裂症阴性症状和认知功能均能影响快感缺失程度。

Objective · To explore the feature and influencing factors of anhedonia in schizophrenia. Methods · A total of 71 schizophrenia patients and 50 healthy controls were recruited during December 2018 and December 2019. Positive and Negative Syndrome Scale (PANSS) was used for assessing psychotic symptoms. Temporal Experience of Pleasure Scale (TEPS) and Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) were applied to the evaluation of anhedonia and cognitive function respectively for each subject. Results · The evaluation result of TEPS showed both anticipatory and consummatory pleasure scores were lowered in patients with schizophrenia than those in healthy people (P=0.000). Stepwise linear regression analysis showed that negative subscale score of PANSS (B=-0.895, P=0.002) and delayed memory score of RBANS (B=0.265, P=0.001) were associated with anhedonia in schizophrenia. Conclusion · Patients with schizophrenia exhibit anticipatory and consummatory anhedonia, both of which are influenced by negative symptoms and delayed memory in schizophrenia.