肿瘤相关成纤维细胞（cancer-associated fibroblasts，CAFs）是存在于肿瘤微环境中的一类重要细胞群。CAFs通过分泌多种可溶性分子重塑细胞外基质，促进肿瘤的生长及侵袭转移。目前认为CAFs在调控肿瘤免疫方面扮演着重要角色，因此越来越多的研究关注于CAFs重塑肿瘤免疫微环境的分子机制。该文从CAFs的分子标志物、CAFs与肿瘤细胞和免疫细胞之间的相互作用以及靶向CAFs的治疗进展等方面做一综述。

Cancer-associated fibroblasts (CAFs) are a major population that resides in the tumor microenvironment. Multiple soluble molecules secreted by CAFs remodel the extracellular matrix, thus promoting tumor growth, invasion and metastasis. It is now considered that CAFs play an important role in the regulation of tumor immunity, in which an increasing number of molecular mechanisms of tumor microenvironment remodeling are being discovered. This article reviews the molecular markers of CAFs, the crosstalk between CAFs and tumor cells or immune cells, as well as the progress on therapeutic targeting of CAFs.