上海交通大学学报（医学版）

上海交通大学学报（医学版） >

2022 , Vol. 42 >Issue 2: 197 - 204

DOI: https://doi.org/10.3969/j.issn.1674-8115.2022.02.010

论著 · 循证医学

白细胞介素-1B-511C/T基因多态性与冠状动脉粥样硬化性心脏病关联的meta分析

  • 谭颖超 ,
  • 杨珺玥 ,
  • 王莉娜
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  • 东南大学公共卫生学院流行病与卫生统计学系，南京 210009
谭颖超（1995—），女，硕士生；电子信箱：220193606@seu.edu.cn。
王莉娜，电子信箱：lnwang@seu.edu.cn。

收稿日期: 2021-09-22

  网络出版日期: 2022-03-17

基金资助

国家自然科学基金(81673259);江苏省自然科学基金(BK20161435);江苏省研究生科研与实践创新计划项目(SJCX20_0062);中央高校基本科研业务费专项资金(3225002108D)

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Association between interleukin-1B-511C/T gene polymorphism and coronary atherosclerotic heart disease: a meta-analysis

  • Yingchao TAN ,
  • Junyue YANG ,
  • Lina WANG
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  • Department of Epidemiology and Biostatistics, School of Public Health, Southeast University, Nanjing 210009, China
WANG Lina, E-mail: lnwang@seu.edu.cn.

Received date: 2021-09-22

  Online published: 2022-03-17

Supported by

National Natural Science Foundation of China(81673259);Natural Science Foundation of Jiangsu Province(BK20161435);Postgraduate Research＆Practice Innovation Program of Jiangsu Province(SJCX20_0062);Fundamental Research Funds for the Central Universities of China(3225002108D)

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摘要

目的·评估白细胞介素-1B（interleukin-1B，IL-1B）-511C/T基因多态性与冠状动脉粥样硬化性心脏病（冠心病）发生风险的关联。方法·检索PubMed、Web of Science、Scopus和Embase数据库中已公开发表的关于IL-1B-511C/T基因多态性与冠心病的病例对照研究。检索时间为各数据库建库至2021年6月。由2名研究人员独立进行文献筛选及数据提取。提取的数据包括第一作者姓名、发表年份、研究对象的种族、匹配因素、对照组来源、基因分型方法、样本量、基因型计数、等位基因计数、是否满足哈迪-温伯格平衡定律。采用Stata 16.0软件进行meta分析。结果·共纳入9篇文献，包括2 190例冠心病患者和2 385例对照者。Meta分析结果显示，IL-1B-511C/T基因多态性与冠心病发生风险间无明显统计学相关（T vs C：OR =1.21，95% CI 0.91~1.61；TT+CT vs CC：OR=1.24，95% CI 0.88~1.75；CC+CT vs TT：OR=1.28，95% CI 0.86~1.90）。亚组分析结果显示，在中国人群中与携带C等位基因和CC基因型的个体相比，携带T等位基因和TT+CT基因型的个体发生冠心病的风险分别增加了85%和116%（T vs C：OR=1.85，95% CI 1.02~3.36；TT+CT vs CC：OR=2.16，95% CI 1.10~4.24）。在以医院为基础的病例对照研究中，与携带CC+CT基因型的人群相比，携带TT基因型的人群发生冠心病的风险增加了59%（OR=1.59，95% CI 1.03~2.47）。结论·IL-1B-511C/T基因多态性与冠心病发生风险间无明显关联。在中国人群中，携带T等位基因和TT+TC基因型的个体的冠心病发生风险较高。

关键词： 白细胞介素-1; 基因多态性; -511C/T; 冠状动脉粥样硬化性心脏病; meta分析

本文引用格式

谭颖超 , 杨珺玥 , 王莉娜 . 白细胞介素-1B-511C/T基因多态性与冠状动脉粥样硬化性心脏病关联的meta分析[J]. 上海交通大学学报（医学版）, 2022 , 42(2) : 197 -204 . DOI: 10.3969/j.issn.1674-8115.2022.02.010

Abstract

Objective

·To evaluate the association between interleukin-1B (IL-1B)-511C/T gene polymorphism and the risk of coronary atherosclerotic heart disease (CHD).

Methods

·Published case-control studies on IL-1B-511C/T gene polymorphism and CHD in PubMed, Web of Science, Scopus and Embase databases were retrieved from the establishment of each database to June 2021. Two researchers independently conducted literature screening and data extraction. The extracted data included the name of the first author, the year of publication, the race of the research objects, matching factors, the source of the control group, genotyping method, sample size, genotype frequency, allele frequency, and whether to meet Hardy-Weinberg equilibrium. Meta-analysis was performed by using Stata 16.0 software.

Results

·A total of 9 literatures were included, including 2 190 patients with CHD and 2 385 controls. Meta-analysis showed that there was no significant correlation between IL-1B -511C/T gene polymorphism and the risk of CHD (T vs C: OR =1.21, 95% CI 0.91?1.61; TT+CT vs CC: OR=1.24, 95% CI 0.88?1.75; CC+CT vs TT: OR=1.28, 95% CI 0.86?1.90). Subgroup analysis showed that compared with individuals with C allele and CC genotype in the Chinese population, the individuals with T allele and TT+CT genotype had a 85% and 116% increased risk of CHD, respectively (T vs C: OR=1.85, 95% CI 1.02?3.36; TT+CT vs CC: OR=2.16, 95% CI 1.10?4.24). In hospital-based case-control studies, compared with individuals with CC+CT genotype, the individuals with TT genotype had a 59% increased risk of CHD (OR=1.59, 95% CI 1.03?2.47).

Conclusion

·There is no significant association between IL-1B-511C/T gene polymorphism and the risk of CHD. In the Chinese population, individuals with T allele and TT+TC genotype have a higher risk of CHD.

Key words： interleukin-1; gene polymorphism; -511C/T; coronary atherosclerotic heart disease (CHD); meta-analysis

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