Abstract:

Objective To investigate the effect of conventional fluid resuscitation combined with ulinastatin treatment on acute lung tissue injury (ALI) in early stage of serious burn. Methods The clinical data of patients with area of burn ≥50% total body surface area (TBSA) or area of burn of III degree ≥20% TBSA (patients with inhalation injury were excluded) were collected and retrospectively analysed. Among the 69 patients, 36 received conventional fluid resuscitation treatment (control group), and the other 33 were managed with conventional fluid resuscitation combined with ulinastatin (UTi group). ALI scoring was performed on the basis of ratio of arterial partial pressure of oxygen (PaO2) to fraction of inspired oxygen (PaO2/FiO2), respiratory frequency and chest X-ray findings before treatment and 1 d, 3 d and 5 d after treatment, and ALI scores and prevalences of ALI were compared between two groups. Results There was no significant difference in ALI scores before treatment and 1 d after treatment between two groups （P>0.05）, while ALI scores in UTi group were significantly lower than those in control group 3 d and 5 d after treatment （P<0.05）. The prevalence of ALI in UTi group was significantly lower than that in control group (45.6% vs 63.9%, P<0.05）. Conclusion Conventional fluid resuscitation combined with ulinastatin treatment decreases the prevalence of ALI in early stage of serious burn, which has protective effect on lung tissues.

Key words: burn, ulinastatin, lung injury, early stage