›› 2011, Vol. 31 ›› Issue (7): 1035-.doi: 10.3969/j.issn.1674-8115.2011.07.037

• Review • Previous Articles     Next Articles

Research progress in immunology of rheumatoid arthritis

MIAO Yi1,2, HU Chao-ying2, QIAN Liu1, ZHANG Dong-qing1   

  1. 1.Shanghai Institute of Immunology, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China；2.Xuhui District Center Hospital of Shanghai, Shanghai 200031, China
  • Online:2011-07-28 Published:2011-07-27
  • Supported by:

    Foundation of Xuhui District Center Hospital of Shanghai, 2011XHCH07；Key Project of Shanghai Science and Technology Committee, 07JC14033, 10JC1408500

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Abstract:

Rheumatoid arthritis (RA) is a common autoimmune disease characterized by chronic inflammation of synovial joints. RA is presented as the malfunction of immune system especially mediated by Th1 cells. B lymphocytes are also closely associated with RA in the process of antigen presentation, antibody generation and cytokine secretion. Besides, γδ T lymphocytes, Th17 cells, interleukin (IL)-4 and IL-10 also function in different stages of RA. This paper discusses the correlation of cells, antibodies and cytokines with the development, diagnosis and treatment of RA.

Key words: rheumatoid arthritis, autoimmune disease, T lymphocyte, B lymphocyte, autoantibody