›› 2012, Vol. 32 ›› Issue (3): 356-.doi: 10.3969/j.issn.1674-8115.2012.03.026

• Review • Previous Articles     Next Articles

Research progress of structure and function of mitochondrial permeability transition pore

FENG Yang, LIU Jian-jun, HUANG Gang   

  1. Department of Nuclear Medicine, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China
  • Online:2012-03-28 Published:2012-03-28
  • Supported by:

    National Natural Science Foundation of China, 30830038


The change of mitochondrial permeability plays an important role in the apoptosis and necrosis of cells, and mitochondria permeability transition pore may influence the change of mitochondrial permeability. However, the molecular structure and function of mitochondria permeability transition pore are not clearly revealed. The research progress of molecules involved in structure composition and function regulation of mitochondria permeability transition pore, including adenine nucleotide translocase (ANT), voltage-dependent anion-selective channel (VDAC), cyclophilin D (Cyp D), phosphatic carrier (PiC) and Bcl-2 proteins is reviewed in this paper.

Key words: mitochondrial permeability transition pore, apoptosis, necrosis