Role of TrkB signal transduction pathway in tumors

doi:10.3969/j.issn.1674-8115.2012.12.027

Abstract

Abstract:

Neurotrophin-tyrosine kinase receptor (NT-Trk) signaling pathway plays an important role in the neural regulation of development. Now it has been recently revealed that Trk may also participate in the pathogenesis of many malignant tumors. It is demonstrated that the expression of TrkB is related to oncogenesis. The activation of brain-derived neurotrophic factor (BDNF)/TrkB signal transduction pathway stimulates tumor cell survival and angiogenesis, and contributes to the resistance to cytotoxic drugs and anoikis. The role of TrkB signal transduction pathway in tumors is reviewed in this paper.

Key words: neurotrophin, tyrosine kinase receptor, brain-derived neurotrophic factor, anoikis resistance, Trk inhibitors

BAO Wei, YU Xiao-hui, WAN Xiao-ping. Role of TrkB signal transduction pathway in tumors[J]. , 2012, 32(12): 1652-.

[1]	Guo-qin HU, Cheng-qing YANG, Qin-yu LÜ, Jing ZHAO, Ming-huan ZHU, Zheng-hui YI, Xin-hai DAI. Effects of computerized cognitive correction therapy on cognitive function of schizophrenia [J]. JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE), 2021, 41(5): 622-627.
[2]	LIU Zhen-qiao, CHEN Qing-qing, WANG Yu-rong. Effect of medium frequency electrical stimulation on expression of neurotrophin-3 in rat masseter muscle [J]. JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE), 2020, 40(05): 604-608.
[3]	YANG Shuang-shuang1, GAO Tian-xing2, HE Xuan1, ZHANG Rui1, ZHANG Yong-fang1. Regulation on brain-derived neurotrophic factor and relevant mechanism of anemarrhena saponin in H2O2-induced SH-SY5Y cells [J]. , 2019, 39(6): 578-.
[4]	LIU Yang, GAO Yu-ting, MIAO Yu-chuan. Effect of Danshen injection on expression of brain-derived neurotrophic factor and insulin-like growth factor-1 in rats with spinal cord injury [J]. , 2018, 38(3): 272-.
[5]	TIAN Jin-ge, YU Ting-ting, ZHANG Xin, DU Dong-ping. Construction of a rat tibial neuroma transposition model and changes of neurotrophin expressions in the nervous system [J]. , 2017, 37(01): 4-.
[6]	ZHANG Rui, XIA Zhi-ming, SUN Xiao-yu, Li Jia-mei, ZHANG Yong-fang, HU Ya-er. Role of ERK/CREB signal pathway in promotion of BDNF expression in Aβ intoxicated SH-SY5Y cells by smilagenin [J]. , 2016, 36(05): 642-.
[7]	YIN Qi, LU Jing-jing, GUO Zhong-liang, et al. Expression of neurotrophin-3 and its receptors in lung tissues of rats with asthma [J]. , 2012, 32(7): 871-.
[8]	ZENG Lu-lu, WANG Jing, ZHANG Xin, et al. Effects of intrathecal injection of exogenous BDNF-activated astrocytes on pain sensation of normal rats [J]. , 2012, 32(7): 881-.
[9]	WANG Jing-hua, XIAO Ze-ping, XIAO Shi-fu, et al. Analysis of expression of brain-derived neurotrophic factor in rats with chronic unpredictable mild stress [J]. , 2012, 32(4): 440-.
[10]	WANG Jing, ZHANG Xin, JIANG Wei, et al. Contribution of BDNF/TrkB pathway to development of neuropathic pain by activation of astrocytes in rats [J]. , 2012, 32(3): 279-.
[11]	JIN Bao, ZHANG Yu-cai, CUI Yun. Effects of erythropoietin on expression of brain-derived neurotrophic factor and tyrosine receptor kinase B after brain injury in mice of different developmental stages [J]. , 2012, 32(1): 14-.
[12]	XU Ya-hong, FANG Wei, YUAN Jiang-zi, et al. Effects of high glucose and methylglyoxal on expression of angiopoietin 2 in cultured human umbilical vascular endothelial cells [J]. , 2011, 31(5): 533-.
[13]	WANG Zuo-wei, LI Ze-zhi, LIN Zhi-guang, et al. Changes of plasma brain-derived neurotrophic factor in patients with bipolar disorder type Ⅰ [J]. , 2011, 31(11): 1532-.
[14]	WANG Jing, ZHANG Xin, DU Dong-ping, et al. Effects of BDNF on activation of spinal dorsal horn astrocytes in rats with spinal nerve ligation [J]. , 2011, 31(11): 1578-.
[15]	HONG Wu, JIANG Kai-da, QIU Jian-ying, et al. Association analysis between tyrosine kinase receptor B gene polymorphisms and major depressive disorder [J]. , 2010, 30(6): 620-.

Role of TrkB signal transduction pathway in tumors

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

TrendMD

References

Related Articles 15

Recommended Articles

Metrics

Comments