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Research status and prospect in dendritic cell vaccine for ovarian cancer

LU Jiang-wen, LI Jia-rui   

  1. Department of Gynecology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
  • Online:2014-01-28 Published:2014-01-29


Ovarian cancer has the highest fatality rate among gynecological cancers. Currently, radical treatment is not yet available. Dendritic cells (DCs), whose sole duty is antigen-presenting, can significantly stimulate the proliferation of naive T cells, thus playing a unique role in immune reaction. Recently, anti-ovarian cancer treatment using DCs vaccine has become one of the hot spots in immunotherapy. This paper reviews the current status of DCs vaccine research, including the preparation and clinical trials of the vaccines, mechanism of DCs affecting carcinoma, and the imperfectness and prospect of this technology.

Key words: ovarian cancer, dendritic cell, immunotherapy