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Advances of insulin-like growth factor Ⅰ signaling pathway and therapeutic target of breast cancer

LIANG Yue, CHEN Xiao-song, SHEN Kun-wei   

  1. Comprehensive Breast Health Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
  • Online:2014-05-28 Published:2014-05-30


The insulin-like growth factor Ⅰ (IGF-Ⅰ) signaling pathway has been found to be closely related to the therapeutic effect of breast cancer. Researches on using the IGF-Ⅰ as a new target for the target therapy of breast cancer have attracted more and more attention. Pre-clinical studies or clinical tests have been conducted for relevant targeted drugs and showed good prospect of basic researches and clinical applications. This paper reviews targeted drugs and research developments of IGF-Ⅰ.

Key words: breast cancer, insulin-like growth factor Ⅰ signaling pathway, target therapy