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Research progresses of apelin in nervous system

WEI Zhen-yu, WU Dan-hong   

  1. Department of Neurology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201999, China
  • Online:2017-05-28 Published:2017-05-31
  • Supported by:

    Science and Technology Commission of Shanghai Fund, 14411972000; Shanghai Jiao Tong University Fund for Interdisciplinary Research on Medicine and Engineering, YG2013MS23; Shanghai Jiao Tong University School of Medicine Fund, 152H2013


Apelin is the endogenous ligand of a G protein-coupled receptor called APJ, its propeptide is an X-linked and coded peptide with 77 amino acids. Apelin/apelin receptor system is widely distributed in the body and is involved in various physiological and pathological regulations. It has been demonstrated that apelin is associated with the occurrence and development of many diseases, including angiocardiopathy, pulmonary arterial hypertension, nephropathy, cancer, endocrine disease, and so on. Currently, studies on apelin in nervous system have been developed gradually. This article focuses on apelin and summarizes the distribution and pathophysiological roles of apelin in nervous system, as well as in the occurrence and development of diseases associated with nervous system.

Key words: apelin, nervous system, brain injury, recognition damage