›› 2019, Vol. 39 ›› Issue (5): 518-.doi: 10.3969/j.issn.1674-8115.2019.05.014

• Original article (Clinical research) • Previous Articles     Next Articles

Value of prostate anterior horn biopsy in the diagnosis of prostate cancer

XIE Shao-wei1, DONG Bai-jun2, XIA Jian-guo1, WANG Yan-qing2, LI Hong-li1, ZHANG Shi-jun1, YANG Wen-qi1, LI Feng-hua1   

  1. 1. Department of Ultrasound, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China; 2. Department of Urology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
  • Online:2019-05-28 Published:2019-07-26
  • Supported by:
    Fund of Science and Technology Commission of Shanghai Municipality, 15411966300; Clinical Auxiliary Departments Ability Construction Project of Shanghai Hospital Development Center, SHDC22015003; Fund of Cultivating Scientific Research Seed Plan of Renji

Abstract: Objective · To evaluate population anterior horn biopsy in the diagnosis of prostate cancer. Methods · The clinical and pathological data of 1 679 patients who underwent ultrasound-guided initial 12-core prostate biopsies at Renji Hospital, Shanghai Jiao Tong University School of Medicine, were retrospectively analyzed. The performances of 12-core (including anterior horn) biopsy and the 10-core (except anterior horn) biopsy were compared in total population and different subgroups for the detection rates of prostate cancer. Results · Of the 1 679 patients, 678 (40.4%) were diagnosed with prostate cancer, and 59 (8.7%) were only positive at anterior horns. After excluding the anterior horn biopsy, the detection rate was 36.9% (619/1 679), which was lower than the overall detection rate including the anterior horn biopsy (40.4% vs 36.9%, P0.046). In prostate specific antigen (PSA) and prostate volume subgroups, for the patients with PSA>10 ng/mL and prostate volume ≥30 mL, the biopsy detection rate was improvedadding the anterior horn biopsy (P<0.05). The patients with only positive anterior horn biopsy had higher prostate volumes and lower Gleason scores, compared with the patients with positive biopasy excluding anterior horn (P0.006, P0.000). Conclusion · Adding the anterior horn biopsy could improve the prostate cancer detection rate, recommended to be routinely used in the initial prostate biopsies.

Key words: prostate cancer, biopsy, anterior horn

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