JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE) ›› 2021, Vol. 41 ›› Issue (7): 953-958.doi: 10.3969/j.issn.1674-8115.2021.07.017

• Review • Previous Articles    

Preparation of cell membrane-coated nanoparticles and its application to antimicrobial

Ting-wang SHI(), Yun-feng CHEN()   

  1. Department of Orthopedic Surgery, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai 200233, China
  • Online:2021-07-28 Published:2021-08-03
  • Contact: Yun-feng CHEN;
  • Supported by:
    National Natural Science Foundation of China(81974340)


Due to the complex pathophysiological characteristics of the infected microenvironment and the development of bacterial resistance, conventional antibiotic treatments are facing increasingly more clinical challenges. Cell membrane-coated nanoparticle (CMCNP) is a kind of biomimetic materials emerging in recent years which can be obtained by directly wrapping the membrane vesicles onto the nanoparticle cores through physical means. Recently, CMCNP has displayed a wide application prospect in the areas of targeting infected areas, neutralization of bacterial toxins and development of antibacterial vaccines with the help of biological functions of cell membrane vesicles and the superior physicochemical properties of nanoparticles. However, CMCNP is still at the experimental stage in the biomedical field, and its safety and effectiveness need to be further verified for clinical applications.

Key words: nanoparticle, cell membrane-coated nanoparticle (CMCNP), biomimetic, targeting infection, neutralization of toxin, antibacterial vaccine

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