Preparation of cell membrane-coated nanoparticles and its application to antimicrobial

doi:10.3969/j.issn.1674-8115.2021.07.017

Abstract

Abstract:

Due to the complex pathophysiological characteristics of the infected microenvironment and the development of bacterial resistance, conventional antibiotic treatments are facing increasingly more clinical challenges. Cell membrane-coated nanoparticle (CMCNP) is a kind of biomimetic materials emerging in recent years which can be obtained by directly wrapping the membrane vesicles onto the nanoparticle cores through physical means. Recently, CMCNP has displayed a wide application prospect in the areas of targeting infected areas, neutralization of bacterial toxins and development of antibacterial vaccines with the help of biological functions of cell membrane vesicles and the superior physicochemical properties of nanoparticles. However, CMCNP is still at the experimental stage in the biomedical field, and its safety and effectiveness need to be further verified for clinical applications.

Key words: nanoparticle, cell membrane-coated nanoparticle (CMCNP), biomimetic, targeting infection, neutralization of toxin, antibacterial vaccine

CLC Number:

R318.08

Ting-wang SHI, Yun-feng CHEN. Preparation of cell membrane-coated nanoparticles and its application to antimicrobial[J]. JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE), 2021, 41(7): 953-958.

Figures/Tables 3

TrendMD

References 45

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Category	Targeting infection	Neutralizing toxin	Vaccine development
Source of cell membrane	Red blood cell， macrophage， platelet， bacteria，neutrophil， gastric epithelial cell	Red blood cell， macrophage， platelet， genetically engineered cell	Red blood cell， bacteria
Core of CMCNP	GSNC， nanomotor， antibiotic-loading PLGA/gelatin/PCL-PEG	PLGA， hydrogel， Fe₃O₄	PLGA
Role of the core	Photothermic therapy， actuation， drug delivery	Stabilizing cell membrane	Stabilizing cell membrane
Antibacterial mechanism	Cell membrane targeting infection， core killing bacteria	Cell membrane adsorbing toxins	Cell membrane adsorbing toxins and stimulating immune response

Category	Targeting infection	Neutralizing toxin	Vaccine development
Source of cell membrane	Red blood cell， macrophage， platelet， bacteria，neutrophil， gastric epithelial cell	Red blood cell， macrophage， platelet， genetically engineered cell	Red blood cell， bacteria
Core of CMCNP	GSNC， nanomotor， antibiotic-loading PLGA/gelatin/PCL-PEG	PLGA， hydrogel， Fe₃O₄	PLGA
Role of the core	Photothermic therapy， actuation， drug delivery	Stabilizing cell membrane	Stabilizing cell membrane
Antibacterial mechanism	Cell membrane targeting infection， core killing bacteria	Cell membrane adsorbing toxins	Cell membrane adsorbing toxins and stimulating immune response

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