JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE) ›› 2021, Vol. 41 ›› Issue (8): 1099-1102.doi: 10.3969/j.issn.1674-8115.2021.08.017

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Biological and angiogenic effects of enamel matrix derivative on periodontal regeneration-related cells

Chi-hsiang CHUANG(), Jia-chen DONG, Rong SHU()   

  1. Department of Periodontology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology, Shanghai 200011, China
  • Online:2021-08-28 Published:2021-08-13
  • Contact: Rong SHU;
  • Supported by:
    National Natural Science Foundation of China(81570977);Project of Science and Technology Commission of Shanghai Municipality(18ZR1422400)


Enamel matrix protein has been proved to promote periodontal regeneration, and later developed into enamel matrix derivative (EMD). At present, EMD has been used in clinic for more than 20 years, and a number of clinical studies have shown that it also has a prominent role in periodontal regeneration. Angiogenesis also plays an essential role in tissue regeneration. This process allows the transportation of numerous cytokines to tissue defect areas via newly formed blood vessel, which can then stimulate periodontal regeneration. Several researches have indicated that EMD can stimulate angiogenesis. In this paper, the effects of EMD on periodontal regeneration-related cells and angiogenesis are reviewed.

Key words: enamel matrix derivative (EMD), angiogenesis, vascular endothelial cell, periodontal regeneration

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