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Quorum sensing inhibitors on biofilm formation

FENG Meng-die1, HONG Yu2, MAO Pu-jia1, XU Ze-yang1, ZENG Wei-kun1,3   

  1. 1.Department of Pathogenic Biology and Immunology, Basic Medicine Faculty, Kunming University of Science and Technology, Kunming 650500, China; 2.Department of Nuclear Medicine, Kunming General Hospital of Chengdu Military Command, Kunming 650032, China; 3.Department of Laboratory Medicine, Kunming University School of Medicine, Kunming 650214, China

  • Online:2016-03-28 Published:2017-06-02
  • Supported by:

    Scientific Research Foundation of Yunnan Educational Committee, 2015Z168; General Program of Yunnan Applied Basic Research Projects, 2012FB135; National Natural Science Foundation of China, 31160193

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Abstract:

Biofilms are complexes resulting from microbial sessile communities attached to a substratum or interface and embedded in a self-produced extracellular matrix, which can provide a protective layer for bacteria, block antibiotic entry, and allow bacteria to exhibit antibiotic resistance. Clinical statistics showed that about 80% of microbial infections are associated with quorum sensing-mediated biofilms. Thus it is essential to inhibit the formation of biofilm in order to cure pathogen infections. Quorum sensing (QS) molecules are involved in biofilm formation, while QS inhibitors (QSI) can inhibit biofilm formation. This papers reviews advances of QSI in anti-biofilm.

Key words: biofilm, quorum sensing, quorum sensing inhibitors