›› 2017, Vol. 37 ›› Issue (12): 1699-.doi: 10.3969/j.issn.1674-8115.2017.12.023

Previous Articles     Next Articles

Introduction and applications of bacteriophage polysaccaride depolymerases

LI Xiao-qian1, WANG Rui1, GU Chuan-jia1, XU Meng-sha1, 2, HE Ping1, HU Fu-pin3   

  1. 1. Department of Medical Microbiology and Parasitology, Basic Medicine Faculty of Shanghai Jiao Tong University, Shanghai 200025, China; 2. College of Pharmacy of
    Zhejiang University of Technology, Hangzhou 310014, China; 3. Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai 200040, China
  • Online:2017-12-28 Published:2018-01-10
  • Supported by:
    National Natural Science Foundation of China, 81471908

Abstract: [Abstract] With the rising detection rate of strains with extensive drug resistance clinically, there is an increasingly urgent need of novel anti-microbial
agents. More and more researchers put emphasis on bacteriophage therapy and have made great progress in this field. A large number of studies showed
that some bacteriophages could produce enzymes which killed the host bacteria by degrading polysaccharides in their extracellular polymeric substances
(EPS). This review introduces the classification of phage polysaccharide depolymerases and their action mode, the methods to determine whether the
phage produces depolymerases, and their applications in anti-bacterial treatment, biofilm degradation and bacterial capsule typing.

Key words: bacteriophage, polysaccharide depolymerase, biofilm, bacterial infection