Research progress of role of innate immunity in infection of leptospira

›› 2010, Vol. 30 ›› Issue (1): 94-.

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Research progress of role of innate immunity in infection of leptospira

DENG Cong¹, reviewer；GUO Xiao-kui², JIANG Xu-cheng¹ reviser

1. Department of Pathology, 2. Department of Microbiology and Parasitology, Basic Medical College, Shanghai Jiaotong University, Shanghai 200025, China

Online:2010-01-26 Published:2010-01-26
Supported by:
National Natural Science Foundation of China, 30770820；Natural Science Foundation of Shanghai, 06ZR14056

Abstract

Abstract:

Leptospirosis is an important zoonosis with worldwide distribution. As the first procedure in immunity system, the role and significance of innate immunity in controlling infection at the early stage of the disease have gradually been emphasized. Macrophages can phagocytize and kill leptospira, while the pathogenic leptospira can evade the killing by macrophages. In addition, neutrophils, complement system and cytokines also contribute to the defence of leptospira infection.

Key words: leptospirosis, innate immunity, macrophage

DENG Cong. Research progress of role of innate immunity in infection of leptospira[J]. , 2010, 30(1): 94-.

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Research progress of role of innate immunity in infection of leptospira

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