›› 2010, Vol. 30 ›› Issue (12): 1565-.doi: 10.3969/j.issn.1674-8115.2010.12.027

• Review • Previous Articles     Next Articles

Research progress of osteogenic effects of osteogenic growth peptide

CHEN Xiao, LUO Bei-er, SU Jia-can   

  1. Department of Orthopaedics, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
  • Online:2010-12-25 Published:2010-12-31


Osteogenic growth peptide (OGP), which bears osteogenic effects, possesses a great potential in clinical use, and has been the focus of intense investigation worldwide. Both animal experiments in vivo and cellular experiments in vitro have demonstrated that OGP can increase bone density, accelerate fracture healing, promote osteogenic functions of osteoblasts, up-regulate expression of core binding factor alpha 1 and type I collagen mRNA, and stimulate proliferation and differentiation of bone marrow mesenchymal stem cells, finally leading to osteogenesis. The research progress of osteogenetic effects of OGP is reviewed in this paper.

Key words: osteogenic growth peptide, osteogenesis, bone marrow mesenchymal stem cells