›› 2010, Vol. 30 ›› Issue (5): 558-.

• Original article (Clinical research) • Previous Articles     Next Articles

Prevalence of metabolic syndrome and analysis of risk factors among patients with maintenance hemodialysis

CHEN Yong-hua1,2, PANG Hui-hua1, ZHU Ming-li1, LU Ren-hua1, ZHOU Wen-yan1, GU Le-yi1, ZHANG Wei-ming1, QIAN Jia-qi1,YAN Yu-cheng1   

  1. 1.Renal Division, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China；2.Department of Nephrology, Shanghai Eighth Hospital, Shanghai 200235, China
  • Online:2010-05-25 Published:2010-05-28
  • Supported by:

    Major Foundamental Research Program of Shanghai Science and Technology Committee, 08DZ1900500

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Abstract:

Objective To investigate the prevalence of metabolic syndrome (MS) in patients with maintenance hemodialysis, and analyse the related risk factors. Methods The clinical data of 202 patients with maintenance hemodialysis were collected. Patients were divided into MS group and non-MS group according to the diagnosis criteria of International Diabetes Federation, and the prevalence of MS was calculated. The demographic data, results of laboratory and anthropometric examinations, dialysis prescription and cardiovascular events were compared among groups. Multivariate Logistic regression analysis was performed to analyse the risk factors for MS. Results The prevalence of MS in 202 patients was 29.2%. There were significant differences in body weight, waist circumference, body mass index, serum levels of glutamate-pyruvate transaminase, cholesterol, triglyceride, low density lipoprotein, high density lipoprotein, fasting blood glucose, C-reactive protein (CRP) and intact parathyroid hormone (iPTH), urea reduction ratio, urea clearance index, hemodialysis frequency and time of hemodialysis per week between two groups (P<0.05). There was no significant difference in the prevalence of cardiovascular events between MS group and non-MS group (25.4% vs 18.2%, P>0.05). Multivariate Logistic regression analysis revealed that iPTH (OR=2.525）, CRP (OR=4.700）, female (OR=8.000）and body weight（OR=24.625）were related with MS. Conclusion MS is not rarely found in patients with maintenance hemodialysis, and high levels of iPTH and CRP, female and obesity are risk factors for MS.

Key words: maintenance hemodialysis, metabolic syndrome, risk factors, prevalence