›› 2010, Vol. 30 ›› Issue (5): 554-.

• Original article (Clinical research) • Previous Articles     Next Articles

Effects of icodextrin dialysate on CA125 level in peritoneal effluent

LIN Ai-wu, QIAN Jia-qi, FANG Wei, NI Zhao-hui, DAI Hui-li, WU Qing-wei   

  1. Renal Division, Center for Peritoneal Dialysis Research, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200001, China
  • Online:2010-05-25 Published:2010-05-28
  • Supported by:

    Shanghai Science and Technology Committee Foundation, 08DZ1900501;Shanghai Education Committee Foundation, 09YZ83;Shanghai Jiaotong University Foundation, BXJ0916

Abstract:

Objective To prospectively observe the changes of carbohydrate antigen 125 (CA125) level in peritoneal effluent after application of icodextrin dialysate, and investigate the effects of icodextrin on peritoneal mesothelial cells. Methods Patients undergoing continuous ambulatory peritoneal dialysis (CAPD) with 2.5% glucose dialysate were selected, and were randomly divided into icodextrin group (treatment with 7.5% icodextrin dialysate for night dwell) and control group (treatment with 2.5% glucose dialysate for night dwell). The therapeutic session lasted 4 weeks, and follow-up was conducted on 14 d and 28 d after treatment. Ultrafiltration volumes and peritoneal creatinine clearance of night dwell were measured at baseline and 14 d and 28 d after treatment. CA125 levels in peritoneal effluent of night dwell at baseline and 28 d after treatment were determined, and CA125 appearance was calculated. Results Fifty-four patients with CAPD were enrolled, with 27 in each group. There was no significant difference in baseline parameters between the two groups (P>0.05). Ultrafiltration volumes and peritoneal creatinine clearance of 14 d and 28 d after treatment in icodextrin group were significantly higher than baseline data, and were significantly higher than those in control group (P<0.05). The differences in CA125 appearance in peritoneal effluent of night dwell between 28 d after treatment and baseline were (1484.0±1571.6) U/h and (-222.1±1816.7) U/h in icodextrin group and control group, respectively (P<0.01). Conclusion Compared with 2.5% glucose dialysate, 7.5% icodextrin dialysate can significantly increase CA125 level in peritoneal effluent, indicating an increase in peritoneal mesothelial cell production.

Key words: peritoneal dialysis, cancer antigen 125, ultrafiltration, creatinine clearance, peritoneal mesothelial cell