›› 2011, Vol. 31 ›› Issue (11): 1588-.doi: 10.3969/j.issn.1674-8115.2011.11.018

• Original article (Clinical research) • Previous Articles     Next Articles

Meta-analysis of XRCC1 Codon 399 polymorphism and susceptibility to hepatocellular carcinoma

CHEN Bing-pu1, LONG Xi-Dai2, FU Guo-hui2   

  1. 1.Department of Anatomy, Youjiang Medical College for Nationalities, Baise 533000, China；2.Department of Pathology, Shanghai Jiaotong University, Shanghai 200025, China
  • Online:2011-11-28 Published:2011-11-29
  • Supported by:

    Youth Science Foundation of Guangxi, 0832097；National Natural Science Foundation of China, 81160255

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Abstract:

Objective To explore the relationship between X-ray repair cross-complementary group 1(XRCC1) codon 399 polymorphism and genetic susceptibility to hepatocellular carcinoma (HCC). Methods Literatures of case-control studies about XRCC1 codon 399 polymorphism and genetic susceptibility to HCC were retrieved, related information was extracted, and meta-analysis was performed on research findings. Odds ratios (ORs) and 95% confidence interval (95% CI) were calculated using fixed- or random-effects model via heterogeneity test, and the publication bias and sensitivity were evaluated. Results Seven domestic and overseas literatures were enrolled, including 1 342 cases of HCC and 2 207 controls. The combined data analysis indicated that XRCC1 codon 399 Gln/Gln increased risk for HCC (OR=1.41, 95% CI=1.07-1.84), while XRCC1 codon 399 Lys/Gln was not related to risk for HCC. Subgroup analysis revealed that both Lys/Gln and Gln/Gln were related to HCC in areas with high incidence of HCC （OR=1.46, 95% CI 1.07-2.00; OR=1.45, 95% CI 1.09-1.93）. Conclusion XRCC1 codon 399 polymorphism is associated with the susceptibility to HCC.

Key words: hepatocellular carcinoma, X-ray repair cross-complementary group 1, meta-analysis, genic polymorphism