›› 2013, Vol. 33 ›› Issue (4): 459-.doi: 10.3969/j.issn.1674-8115.2013.04.016

• Original article (Clinical research) • Previous Articles     Next Articles

Correlation of thrombelastogram with platelet aggregation rate and D-dimer in patients with acute cerebral infarction

ZHOU Xi-lin1,2, LIANG Hui1,2, HUANG Jie-jie1   

  1. 1.Department of Hematology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China； 2.Department of Geriatrics, Chongming Branch of Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 202150, China
  • Online:2013-04-28 Published:2013-05-03
  • Supported by:

    Chongming County Science and Technology Committee Foundation, CK-2011-31

PDF (PC)

1419

Abstract:

Objective To investigate the correlation of parameters of thrombelastogram (TEG) with platelet aggregation rate (PAgT) and D-dimer in patients with acute cerebral infarction. Methods One hundred and two patients with acute cerebral infarction were selected, and were divided into mild acute cerebral infarction group (n=41), moderate acute cerebral infarction group (n=35) and severe acute cerebral infarction group (n=26) according to the scores of severity of neurological deficit. Besides, 50 healthy subjects were served as control group. All subjects were examined with the parameters of TEG (including R value, K value, α angle, MA value and CI value), PAgT and D-dimer. Results R-value and K value were significantly smaller, α angle, MA value and CI value were significantly larger and the D-dimer and PAgT levels were significantly higher in patients with acute cerebral infarction than in control group (P<0.01). The parameters of TEG and levels of PAgT and D-dimer in severe acute cerebral infarction group were significantly different from those in mild acute cerebral infarction group and moderate acute cerebral infarction group (P<0.05). The parameters of TEG and PAgT level in moderate acute cerebral infarction group were significantly different from those in mild acute cerebral infarction group (P<0.05), while there was no significant difference in D-dimer level between these two groups (P＞0.05). Pearson correlation analysis revealed that the D-dimer and PAgT levels were positively related to α angle, MA value and CI level (P<0.01), and were negatively related to R-value and K value (P<0.01). Conclusion The parameters of TEG are significantly related to the D-dimer and PAgT levels in patients with acute cerebral infarction. TEG plays a role in the diagnosis of acute cerebral infarction, evaluation of severity of acute cerebral infarction and monitoring of hypercoagulable state.

Key words: acute cerebral infraction, thrombelastograph, platelet aggregation rate, D-dimer