Objective To investigate the prevalence of anxiety and depression in patients with untreated osteonecrosis of the femoral head (ONFH), and explore the potential risk factors. Methods A total of 235 patients with untreated ONFH were consecutively enrolled from January 2010 to December 2010. Seventeen items including demographic characteristics, living habit, history of ONFH and history of other diseases were investigated with self-designed questionnaire. Zung self-rating anxiety scale (SAS) and Zung self-rating depression scale (SDS) were employed to assess the prevalence of anxiety and depression. The risk factors of prevalence of anxiety and depression in patients with ONFH were explored with univariate and multivariate analysis. Results Two hundred and sixteen effective questionnaires were recovered, with the effective rate of 91.91%. The prevalence of anxiety was 20.4%, that of depression was 21.8%, and that of anxiety complicated with depression was 15.7%. Univariate analysis revealed that inducement of necrosis, stage of necrotic severity, unilateral or bilateral necrosis, VAS score and Harris score were risk factors of anxiety (P<0.05), and working state, inducement of necrosis, stage of necrotic severity, gender, history of concomitant diseases, unilateral or bilateral necrosis and Harris score were risk factors of depression (P＜0.05). Multivariate analysis indicated that risk factors of prevalence of anxiety included unilateral or bilateral necrosis of the femoral head (OR=3.159, 95%CI: 1.492-6.682) and stage of necrotic severity (OR=2.443, 95%CI: 1.417-4.211), and risk factors of prevalence of depression included gender (OR=2.941, 95%CI: 1.476-5.863), history of concomitant diseases (OR=4.091, 95%CI: 1.906-8.779) and stage of necrotic severity (OR=4.529, 95%CI: 2.425-8.458). Conclusion Patients with untreated ONFH are associated with higher prevalence of anxiety and depression, and targeted intervention should be performed.
