Abstract:

Tumors are often accompanied by genetic and epigenetic changes. Histone modifications, as the important epigenetic regulation, are frequently involved in the initiation and progression of tumors. Recent studies have revealed that some JmjC domain-containing proteins with histone demethylase activity can remove the histone methyl. JmjC family play an important role in the oncogenesis, the mechanism of which has been the hotspot of tumor epigenetic research. This review introduces the general information of JmjC family members, and discusses their role on tumorigenesis.

Key words: JmjC family, tumor, epigenetics