›› 2013, Vol. 33 ›› Issue (5): 676-.doi: 10.3969/j.issn.1674-8115.2013.05.034

• Review • Previous Articles     Next Articles

Research progress of role of JmjC family in tumorigenesis

WU Bing-hao1, WANG Yu-ping1,2, HAN Ze-guang1   

  1. 1.Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China; 2.Institute of Medical Biochemistry and Molecular Biology, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China
  • Online:2013-05-28 Published:2013-05-28
  • Supported by:

    National Natural Science Foundation of China, 81071722, 81101875


Tumors are often accompanied by genetic and epigenetic changes. Histone modifications, as the important epigenetic regulation, are frequently involved in the initiation and progression of tumors. Recent studies have revealed that some JmjC domain-containing proteins with histone demethylase activity can remove the histone methyl. JmjC family play an important role in the oncogenesis, the mechanism of which has been the hotspot of tumor epigenetic research. This review introduces the general information of JmjC family members, and discusses their role on tumorigenesis.

Key words: JmjC family, tumor, epigenetics