›› 2013, Vol. 33 ›› Issue (6): 874-.doi: 10.3969/j.issn.1674-8115.2013.06.035

• Review • Previous Articles     Next Articles

Research progress of candidate gene of age at natural menopause

SUN Dong-mei, TAO Min-fang   

  1. Department of Obstetrics and Gynecology, the Sixth People's Hospital, Shanghai Jiaotong University, Shanghai 200233, China
  • Online:2013-06-28 Published:2013-06-28


Age at natural menopause (ANM) is a complex trait which is determined by genes and environment, and the genetic effects are prominent. Early or delayed menopause is associated with female-related diseases. Exploring genetic factors of ANM can help to predict the potential health problems of postmenopausal women, and may provide appropriate health guidance. It has been found by genome-wide association studies and candidate gene association studies that several genes are associated with ANM. The research progress of candidate genes of ANM is reviewed in this paper.

Key words: age at natural menopause, candidate gene, single nucleotide polymorphisms