• Original article (Clinical research) • Previous Articles     Next Articles

Impact of glutathione system on coronary heart diseases

YANG Hui1, ZHAO Ya-jie2, YU Qiang1, LI Fei-ka2, LIANG Wei2   

  1. 1.Department of Cardiology, Central Hospital of Minhang District, Ruijin Hospital Group, Shanghai 201100, China; 2.Department of Gerontology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
  • Online:2013-09-28 Published:2013-09-29


Objective To investigate the impact of glutathione system on coronary heart disease. Methods One hundred and seventy-nine patients undergoing coronary angiography were selected, and were divided into elder group (≥60 years old, n=102) and non-elder group (<60 years old, n=77). The blood biochemical parameters were examined, and the activity of  glutathione peroxidase (GSH-Px), glutathione (GSH) and glutathione reductase (GR) was detected. The severity of coronary atherosclerosis was determined by Gensini score system based on the findings of coronary angiography. Results There was no significant difference in blood biochemical parameters between two groups (P>0.05). The plasma activity of  GSH, GSH-Px and GR in elder group was significantly lower than that in non-elder group (P<0.05). After adjustment for age, the plasma activity of GSH, GSH-Px and GR  was significantly negatively related to Gensini scores (r=-0.721, -0.743 and -0.724; P<0.001). Based on the quartile of Gensini scores, with the increase of Gensini scores, the activity of GSH, GSH-Px and GR decreased gradually (P<0.001). Multiple linear regression analysis indicated that the activity of GSH-Px had the greatest impact on Gensini scores. Conclusion With the age increase, the plasma activity of GSH, GSH-Px and GR significantly decreases, and is negatively related to the severity of coronary artery stenosis, especially for GSH-Px.

Key words: glutathione peroxidase, glutathione, glutathione reductase, aging, coronary heart disease, Gensini score