›› 2017, Vol. 37 ›› Issue (7): 964-.doi: 10.3969/j.issn.1674-8115.2017.07.014

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Predictive value of circulating endothelial progenitor cells in prognosis of acute ischemic stroke

YUE Dan-dan1,2, WEI Zhen-yu1, CHEN Xin1, WANG Jia-yan1, LU Wen-mei1, ZHONG Ping3, WU Dan-hong1   

  1. 1. Department of Neurology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201999, China; 2. Department of Cardiology, Shidong Hospital, Shanghai 200438, China; 3. Department of Encephalopathy, Shanghai TCM-integrated Hospital, Shanghai University of TCM, Shanghai 200082, China
  • Online:2017-07-28 Published:2017-08-25
  • Supported by:
     Scientific Research Project of Science and Technology Committee of Shanghai Municipality, 14411972000; Scientific Research Project of Shanghai Municipal Commission of Health and Family Planning , 201440332; Innovation Fund for Translational Medicine in Shanghai Jiao Tong University School of Medicine,152H2013

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Abstract: Objective · To study the change of circulating endothelial progenitor cells (cEPCs) in acute ischemic stroke (AIS) patients within one week after attack, and the correlation of cEPCs with the prognosis.  Methods · Ninty-two patients with AIS (AIS group) and 20 patients with risk factors (Risk group) were recruited. The proportion of cEPCs (CD34+KDR+ cells) in peripheral blood mononuclear cells of AIS patients was measured  by flow cytometry (FCM) on the first day of admission and the seventh day after attack. Functional recovery was assessed by modified Rankin Scale (mRS) on the 90th day after onset. The cEPCs percentages of AIS patients with different mRS were compared to analyze their correlation.  Results · Compared with Risk group, cEPCs percentage of AIS group on the 1st day of admission was lower (P=0.016). In AIS group, compared with poor prognosis group (mRS>2), cEPCs percentage of good prognosis group on the 7th day after onset (mRS ≤ 2) elevates (P=0.002). The result of multiple linear regression showed that cEPCs percentage on the 7th day after onset was positively correlated with mRS on the 90th day (t=4.608, P=0.011).  Conclusion · The percentage of cEPCs in peripheral blood of AIS patients decreases significantly during the acute phase. The percentage on the 7th day after onset is correlated with prognosis of AIS patients.

Key words:  acute ischemic stroke, circulating endothelial progenitor cell, modified Rankin Scale, prognosis