Abstract: Objective · To investigate the risk factors for gestational diabetes mellitus (GDM) among multiparae. Methods · Women who had two consecutive pregnancies records in the International Peace Maternity and Child Health Hospital January 2012 to January 2017 were included into this study. The case group (116 cases) and control group (464 cases) were matched at the ratio of 1:4 according to the pre-pregnancy age in index pregnancy. Clinical characteristics, biochemical parameters including oral glucose tolerance test (OGTT) and lipid profiles were took into considerationvirtue of their medical records. Multivariate Logistic regression analysis was used to compute the adjusted odds ratio (aOR) and 95%CI so as to identify the risk factors. Results · Compared with the control group, the case group was associated with greater body mass index (BMI) change between pregnancies(aOR1.35, 95% CI1.07-1.69), greater postprandial 1 h glucose load (aOR1.99, 95% CI1.55-2.55) and 2 h glucose load (aOR2.02, 95% CI1.512.70)at OGTT in index pregnancy, and greater first-trimester fasting plasma glucose (aOR1.96, 95% CI1.16-3.32), total cholesterol (aOR1.37,95% CI1.06-1.77) and triacylglycerol (aOR1.53, 95% CI1.10-2.14) in subsequent pregnancy. Conclusion · The elevated BMI change between pregnancies, the abnormal glucose and lipid profiles persisting index to subsequent pregnancy lead to the occurrence of GDM.

Key words: multipara, gestational diabetes mellitus, risk factor, biochemical parameter, case-control study