JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE) ›› 2021, Vol. 41 ›› Issue (12): 1636-1641.doi: 10.3969/j.issn.1674-8115.2021.12.013

• Clinical research • Previous Articles    

Relation between body mass index and left ventricular structure and function in patients with hypertrophic cardiomyopathy: a cardiovascular magnetic resonance imaging study

Ye-zi CHAI(), Meng JIANG(), Jun PU()   

  1. Department of Cardiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
  • Received:2021-08-04 Online:2021-12-28 Published:2022-01-28
  • Contact: Meng JIANG,Jun PU;;
  • Supported by:
    National Natural Science Foundation of China(81971570);Shanghai Shenkang Hospital Development Center Three-year Action Plan: Promoting Clinical Skills and Innovation in Municipal Hospital(SHDC2020CR2025B);Innovation Research Project of Shanghai Science and Technology Commission(20Y11910500);Advanced Technology Leader of the Shanghai Science and Technology Commission(21XD143210);Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support(20172014);Shanghai Pudong Municipal Health Commission-Joint Research Project(PW2018D-03);Medical-Engineering Cross Research of Shanghai Jiao Tong University(YG2019ZDA13);Medical-Engineering Cross Research of University of Shanghai for Science and Technology(10-20-302-425)

Abstract: Objective

·To evaluate the relation between body mass index (BMI) and left ventricular structure and function in patients with hypertrophic cardiomyopathy (HCM) through cardiovascular magnetic resonance (CMR).


·Twenty-two healthy people (control group) and 92 consecutive patients with HCM (HCM group) who received treatment in the Department of Cardiology of Renji Hospital, Shanghai Jiao Tong University School of Medicine were included from January 2016 to December 2020, and all participants completed CMR examination under the scrutiny of cardiologists and radiologists. Patients with HCM were grouped according to BMI index: the normal BMI subgroup (BMI<24.00 kg/m2), the overweight subgroup (24.00 kg/m2≤BMI<28.00 kg/m2) and the obesity subgroup (BMI≥28.00 kg/m2). The structural and functional indexes of CMR between the HCM group and the control group and among the three HCM subgroups were compared, including left ventricular end-diastolic volume (LVEDV), left ventricular end-systolic volume (LVESV), left ventricular ejection fraction (LVEF), left ventricular mass index (LVMI) and global longitudinal strain (GLS). The relationship between BMI and GLS was explored by stepwise linear analysis.


·The HCM group had higher LVEF (P=0.001), higher LVMI (P=0.000) and lower GLS (P=0.000) compared with the control group. LVEDV increased (both P=0.000) and GLS decreased (P=0.005, P=0.000) in the overweight and the obesity subgroup compared with the normal BMI subgroup. In the stepwise linear regression, it suggested that BMI in patients with HCM was associated with decreased GLS independently after being adjusted for age (β=-0.431, P=0.000).


·BMI is negatively correlated with the left ventricular structure and function in patients with HCM. Losing weight to keep BMI in normal range may help to improve left ventricular function and clinical prognosis.

Key words: hypertrophic cardiomyopathy (HCM), cardiovascular magnetic resonance (CMR), body mass index (BMI), global longitudinal strain (GLS)

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