JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE) ›› 2021, Vol. 41 ›› Issue (7): 963-966.doi: 10.3969/j.issn.1674-8115.2021.07.019

• Review • Previous Articles    

Clinical research progress of Janus kinase inhibitors in the treatment of atopic dermatitis

Hao-jun ZHUANG(), Mei-liang GUO, Wan-wen LIU, Hui DENG()   

  1. Department of Dermatology, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai 200233, China
  • Online:2021-07-28 Published:2021-08-03
  • Contact: Hui DENG E-mail:nichijou@sjtu.edu.cn;denghui-1@hotmail.com
  • Supported by:
    National Natural Science Foundation of China(81673054)

Abstract:

Atopic dermatitis is a chronic inflammatory skin disease, which is mainly related to changes in Th2 type signaling pathways. Increased expression of interleukin-4 (IL-4) and IL-13 reduces filaggrin, which leads to skin barrier defects. The Janus kinase-singal transducer and activator of transcriprion (Jak-STAT) signaling pathway is closely related to the pathogenesis of atopic dermatitis. Inhibiting the Jak-STAT signaling pathway is a potential method to treat atopic dermatitis. Janus kinase (JAK) inhibitors can be divided into first-generation and second-generation JAK inhibitors in the selection of JAKs′ inhibition. By summarizing the efficacy and safety of the first-generation and second-generation JAK inhibitors in clinical trials, the clinical research progress of JAK inhibitors in the treatment of atopic dermatitis is clarified.

Key words: atopic dermatitis, Jak-STAT signaling pathway, JAK inhibitors

CLC Number: