Review of the role of collagen in tumorigenesis and development

doi:10.3969/j.issn.1674-8115.2023.12.014

Abstract

Abstract:

Collagen is one of the most abundant proteins in the body and is the main component of the extracellular matrix. Collagen regulates cellular behavior, and its dysregulation can cause a variety of diseases, including cancer. Collagen in tumors is mainly produced by fibroblasts and plays an important role in cancer progression and metastasis. Collagen can act as a prognostic predictor for cancer patients and may be an effective target for the treatment and prevention of tumor progression and metastasis. Anti-tumor drugs targeting collagen and its receptors may be developed in the future. This review focuses on the newly discovered role of collagen in cancer in recent years, specifically the role of collagen in tumor cell dormancy and immune evasion, and the participation of collagen in tumor cell metabolism.

Key words: collagen, extracellular matrix, cancer progression, tumor metastasis, immune escape

CLC Number:

R730.2

TANG Lei, XU Yingchun, ZHANG Fengchun. Review of the role of collagen in tumorigenesis and development[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2023, 43(12): 1577-1584.

Figures/Tables 1

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References 72

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Receptor	Cell type	Collagen type
Integrin α1β1	Mesenchymal cells, inflammatory cells (T lymphocytes), epithelial cells, platelets	Collagen Ⅳ and Ⅵ, fibril-forming collagens
Integrin α2β1	Mesenchymal cells, epithelial cells, platelets	Fibril-forming collagens
Integrin α10β1	Chondrocytes	Collagen Ⅳ and Ⅵ
Integrin α11β1	Mesenchymal cells	Fibril-forming collagens and collagen Ⅹ
DDR1	Epithelial cells	Fibril-forming collagens (Collagen Ⅰ, Ⅱ, Ⅲ), Collagen Ⅳ and Ⅷ
DDR2	Mesenchymal cells	Fibril-forming collagens and collagen Ⅹ
GPVI	Platelets	Fibril-forming collagens
LAIR-1, LAIR-2	Leukocytes	Collagen I, transmembrane collagens 􀃼, ⅩⅦ, Ⅹ􀃼
OSCAR	Vascular endothelial cells, osteoclast, macrophages	Fibril-forming collagens (Collagen Ⅰ, Ⅱ, Ⅲ)
GPR56	Platelets	Fibril-forming collagens (i.e., Collagen Ⅲ)
Mannose receptor family (MR, PLA2R, DEC-205, Endo180)	Fibroblasts	Fibril-forming collagens and collagen Ⅳ

Receptor	Cell type	Collagen type
Integrin α1β1	Mesenchymal cells, inflammatory cells (T lymphocytes), epithelial cells, platelets	Collagen Ⅳ and Ⅵ, fibril-forming collagens
Integrin α2β1	Mesenchymal cells, epithelial cells, platelets	Fibril-forming collagens
Integrin α10β1	Chondrocytes	Collagen Ⅳ and Ⅵ
Integrin α11β1	Mesenchymal cells	Fibril-forming collagens and collagen Ⅹ
DDR1	Epithelial cells	Fibril-forming collagens (Collagen Ⅰ, Ⅱ, Ⅲ), Collagen Ⅳ and Ⅷ
DDR2	Mesenchymal cells	Fibril-forming collagens and collagen Ⅹ
GPVI	Platelets	Fibril-forming collagens
LAIR-1, LAIR-2	Leukocytes	Collagen I, transmembrane collagens 􀃼, ⅩⅦ, Ⅹ􀃼
OSCAR	Vascular endothelial cells, osteoclast, macrophages	Fibril-forming collagens (Collagen Ⅰ, Ⅱ, Ⅲ)
GPR56	Platelets	Fibril-forming collagens (i.e., Collagen Ⅲ)
Mannose receptor family (MR, PLA2R, DEC-205, Endo180)	Fibroblasts	Fibril-forming collagens and collagen Ⅳ

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