Journal of Shanghai Jiao Tong University (Medical Science) ›› 2024, Vol. 44 ›› Issue (4): 474-481.doi: 10.3969/j.issn.1674-8115.2024.04.008
• Clinical research • Previous Articles
SONG Chenlu(), XIANG Jun, YANG Huizhong()
Received:
2024-01-29
Accepted:
2024-03-07
Online:
2024-04-28
Published:
2024-04-28
Contact:
YANG Huizhong
E-mail:songchenlu@163.com;401135865@qq.com
Supported by:
CLC Number:
SONG Chenlu, XIANG Jun, YANG Huizhong. Early alarming effect of serum heparin-binding protein on prognosis and occurrence of sepsis in severely burned patients[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2024, 44(4): 474-481.
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URL: https://xuebao.shsmu.edu.cn/EN/10.3969/j.issn.1674-8115.2024.04.008
Item | Death (n=12) | Survival (n=40) | t/χ2 value | P value |
---|---|---|---|---|
Gender/n(%) | 0.402 | 0.526 | ||
Male | 10 (83.33) | 36 (90.00) | ||
Female | 2 (16.67) | 4 (10.00) | ||
Age/year | 54.17±15.25 | 44.43±13.25 | -2.158 | 0.036 |
Percentage of TBSA/% | 82.50±10.66 | 71.55±14.08 | -2.482 | 0.165 |
Endotracheal intubation or tracheotomy/n(%) | 11 (91.67) | 26 (65.00) | 3.198 | 0.074 |
BMI/(kg·m-2) | 22.42±3.42 | 24.20±3.15 | 1.680 | 0.098 |
Tab 1 Comparison of the general situation of death and survival groups
Item | Death (n=12) | Survival (n=40) | t/χ2 value | P value |
---|---|---|---|---|
Gender/n(%) | 0.402 | 0.526 | ||
Male | 10 (83.33) | 36 (90.00) | ||
Female | 2 (16.67) | 4 (10.00) | ||
Age/year | 54.17±15.25 | 44.43±13.25 | -2.158 | 0.036 |
Percentage of TBSA/% | 82.50±10.66 | 71.55±14.08 | -2.482 | 0.165 |
Endotracheal intubation or tracheotomy/n(%) | 11 (91.67) | 26 (65.00) | 3.198 | 0.074 |
BMI/(kg·m-2) | 22.42±3.42 | 24.20±3.15 | 1.680 | 0.098 |
Item | Sepsis (n=29) | Non-sepsis (n=23) | t/Z/χ2 value | P value |
---|---|---|---|---|
Gender/n(%) | 0.327 | 0.568 | ||
Male | 25 (86.21) | 21 (91.30) | ||
Female | 4 (13.79) | 2 (8.70) | ||
Age/year | 47.62±13.32 | 44.43±13.25 | -0.537 | 0.554 |
Percentage of TBSA/% | 85.00 (75.00, 89.50) | 61.00 (53.00, 75.00) | 2.393 | 0.011 |
Endotracheal intubation or tracheotomy/n(%) | 26 (89.66) | 11 (47.83) | 10.930 | 0.001 |
BMI/(kg·m-2) | 23.60±3.43 | 24.04±3.12 | 0.481 | 0.636 |
Prognosis/n(%) | 0.751 | 0.386 | ||
Survival | 21 (72.41) | 19 (82.61) | ||
Death | 8 (27.59) | 4 (17.39) |
Tab 2 Comparison of the general situation of patients with and without sepsis
Item | Sepsis (n=29) | Non-sepsis (n=23) | t/Z/χ2 value | P value |
---|---|---|---|---|
Gender/n(%) | 0.327 | 0.568 | ||
Male | 25 (86.21) | 21 (91.30) | ||
Female | 4 (13.79) | 2 (8.70) | ||
Age/year | 47.62±13.32 | 44.43±13.25 | -0.537 | 0.554 |
Percentage of TBSA/% | 85.00 (75.00, 89.50) | 61.00 (53.00, 75.00) | 2.393 | 0.011 |
Endotracheal intubation or tracheotomy/n(%) | 26 (89.66) | 11 (47.83) | 10.930 | 0.001 |
BMI/(kg·m-2) | 23.60±3.43 | 24.04±3.12 | 0.481 | 0.636 |
Prognosis/n(%) | 0.751 | 0.386 | ||
Survival | 21 (72.41) | 19 (82.61) | ||
Death | 8 (27.59) | 4 (17.39) |
Item | Non-septic shock (n=19) | Septic shock (n=10) | t/χ2 value | P value |
---|---|---|---|---|
Gender/n(%) | 3.372 | 0.105 | ||
Male | 18 (94.74) | 7 (70.00) | ||
Female | 1 (5.26) | 3 (30.00) | ||
Age/year | 47.26±14.94 | 48.30±10.25 | 0.196 | 0.846 |
Percentage of TBSA/% | 79.79±10.78 | 85.30±8.08 | 1.416 | 0.168 |
Endotracheal intubation or tracheotomy/n(%) | 17 (89.47) | 9 (90.00) | 0.002 | 0.965 |
BMI/(kg·m-2) | 23.98±3.45 | 22.87±3.46 | -0.826 | 0.416 |
Tab 3 Comparison of the general situation of patients with and without septic shock
Item | Non-septic shock (n=19) | Septic shock (n=10) | t/χ2 value | P value |
---|---|---|---|---|
Gender/n(%) | 3.372 | 0.105 | ||
Male | 18 (94.74) | 7 (70.00) | ||
Female | 1 (5.26) | 3 (30.00) | ||
Age/year | 47.26±14.94 | 48.30±10.25 | 0.196 | 0.846 |
Percentage of TBSA/% | 79.79±10.78 | 85.30±8.08 | 1.416 | 0.168 |
Endotracheal intubation or tracheotomy/n(%) | 17 (89.47) | 9 (90.00) | 0.002 | 0.965 |
BMI/(kg·m-2) | 23.98±3.45 | 22.87±3.46 | -0.826 | 0.416 |
Item | Death (n=12) | Survival (n=40) | t/χ2 value | P value |
---|---|---|---|---|
HBP/(ng·mL-1) | 201.92 (156.12, 260.82) | 101.96 (20.02, 168.90) | 3.306 | 0.002 |
WBC/(×109·L-1) | 22.96±8.72 | 21.81±10.14 | 0.354 | 0.725 |
CRP/(mg·L-1) | 108.47 (3.35, 212.60) | 65.78 (6.15, 108.28) | 1.705 | 0.094 |
PCT/(μg·L-1) | 4.50 (1.43, 6.78) | 4.47 (0.50, 5.45) | 0.010 | 0.286 |
APACHE Ⅱ/score | 18.50±2.65 | 17.00±1.87 | 2.208 | 0.032 |
SOFA/score | 15.33±2.64 | 14.98±1.85 | 0.532 | 0.597 |
Tab 4 Comparison of laboratory results, APACHE Ⅱ and SOFA scores in different prognosis groups of patients
Item | Death (n=12) | Survival (n=40) | t/χ2 value | P value |
---|---|---|---|---|
HBP/(ng·mL-1) | 201.92 (156.12, 260.82) | 101.96 (20.02, 168.90) | 3.306 | 0.002 |
WBC/(×109·L-1) | 22.96±8.72 | 21.81±10.14 | 0.354 | 0.725 |
CRP/(mg·L-1) | 108.47 (3.35, 212.60) | 65.78 (6.15, 108.28) | 1.705 | 0.094 |
PCT/(μg·L-1) | 4.50 (1.43, 6.78) | 4.47 (0.50, 5.45) | 0.010 | 0.286 |
APACHE Ⅱ/score | 18.50±2.65 | 17.00±1.87 | 2.208 | 0.032 |
SOFA/score | 15.33±2.64 | 14.98±1.85 | 0.532 | 0.597 |
Item | Sepsis (n=29) | Non-sepsis (n=23) | t/χ2 value | P value |
---|---|---|---|---|
HBP/(ng·mL-1) | 144.84 (38.27, 258.40) | 75.13 (21.36, 98.70) | 2.556 | 0.014 |
WBC/(×109·L-1) | 24.07±9.85 | 19.55±9.26 | 1.688 | 0.098 |
CRP/(mg·L-1) | 83.99 (11.30, 135.25) | 65.09 (4.90, 116.40) | 0.872 | 0.680 |
PCT/(μg·L-1) | 5.12 (0.79, 6.32) | 3.05 (0.52, 1.17) | 1.078 | 0.286 |
APACHE Ⅱ/score | 18.21±2.16 | 16.26±1.57 | 3.621 | 0.032 |
SOFA/score | 15.86±1.86 | 14.04±1.80 | 3.549 | 0.001 |
Tab 5 Comparison of laboratory results, APACHE Ⅱ and SOFA scores in different groups of patients with and without sepsis
Item | Sepsis (n=29) | Non-sepsis (n=23) | t/χ2 value | P value |
---|---|---|---|---|
HBP/(ng·mL-1) | 144.84 (38.27, 258.40) | 75.13 (21.36, 98.70) | 2.556 | 0.014 |
WBC/(×109·L-1) | 24.07±9.85 | 19.55±9.26 | 1.688 | 0.098 |
CRP/(mg·L-1) | 83.99 (11.30, 135.25) | 65.09 (4.90, 116.40) | 0.872 | 0.680 |
PCT/(μg·L-1) | 5.12 (0.79, 6.32) | 3.05 (0.52, 1.17) | 1.078 | 0.286 |
APACHE Ⅱ/score | 18.21±2.16 | 16.26±1.57 | 3.621 | 0.032 |
SOFA/score | 15.86±1.86 | 14.04±1.80 | 3.549 | 0.001 |
Variable | β | SE | P value | OR | 95%CI |
---|---|---|---|---|---|
WBC | -0.003 | 0.045 | 0.944 | 0.997 | -0.122‒0.109 |
HBP | 0.011 | 0.004 | 0.013 | 1.011 | 1.001‒1.095 |
CRP | 0.004 | 0.005 | 0.460 | 1.004 | -0.015‒0.190 |
PCT | -0.041 | 0.064 | 0.518 | 0.960 | -0.240‒0.148 |
Tab 6 Logistic regression analysis of the risk factors affecting the death of severely burned patients
Variable | β | SE | P value | OR | 95%CI |
---|---|---|---|---|---|
WBC | -0.003 | 0.045 | 0.944 | 0.997 | -0.122‒0.109 |
HBP | 0.011 | 0.004 | 0.013 | 1.011 | 1.001‒1.095 |
CRP | 0.004 | 0.005 | 0.460 | 1.004 | -0.015‒0.190 |
PCT | -0.041 | 0.064 | 0.518 | 0.960 | -0.240‒0.148 |
Variable | β | SE | P value | OR | 95%CI |
---|---|---|---|---|---|
WBC | 0.003 | 0.064 | 0.965 | 1.003 | -1.735‒6.315 |
HBP | 0.013 | 0.006 | 0.048 | 1.013 | 0.001‒2.064 |
CRP | 0.013 | 0.009 | 0.149 | 1.013 | -0.013‒1.575 |
PCT | 0.033 | 0.071 | 0.645 | 0.968 | -12.644‒2.125 |
Tab 7 Logistic regression analysis of risk factors affecting the occurrence of septic shock in severely burned patients with sepsis
Variable | β | SE | P value | OR | 95%CI |
---|---|---|---|---|---|
WBC | 0.003 | 0.064 | 0.965 | 1.003 | -1.735‒6.315 |
HBP | 0.013 | 0.006 | 0.048 | 1.013 | 0.001‒2.064 |
CRP | 0.013 | 0.009 | 0.149 | 1.013 | -0.013‒1.575 |
PCT | 0.033 | 0.071 | 0.645 | 0.968 | -12.644‒2.125 |
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