Abstract:

Objective  To explore the relationship between serum homocysteine (Hcy) and leukoaraiosis (LA). Methods  Patients with LA who were admitted and treated from May 2013 to May 2014 were selected as subjects and divided into LA group (n=164) and non-LA group (n=104) according to the incidence of LA. Clinical data of two groups (gender, age, hypertension, diabetes, smoking, alcohol consumption, blood lipid, plasma fibrinogen, fasting blood glucose, D-dimer, uric acid, albumin, and Hcy) were collected. Univariate analysis and multivariate logistic regression analysis were used to analyze risk factors relevant to LA. Results  Hcy levels of LA group [(15.57±6.22) μmol/L] were higher than those of non-LA group [(12.74±4.93) μmol/L] and the difference between two groups was statistically significant (P<0.001). The multivariate Logistic regression analysis showed that Hcy (P=0.041; OR: 1.118; 95%CI: 1.004-1.245) was independently correlated with the incidence of LA. Conclusion  Hcy is an independent risk factor of leukoaraiosis.

Key words: homocystein, leukoaraiosis, risk factor